9MZR
cryoEM structure of GluK2 LBD-TMD bound to BPAM344 and glutamate in the non-active state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Glutamate receptor ionotropic, kainate 2 | polymer | 908 | 102547.0 | 4 | UniProt (P42260) | Rattus norvegicus (Norway rat) | |
| 2 | E, F, I, J (A, C) | 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide | non-polymer | 242.3 | 4 | Chemie (2J9) PubChem (67531324) | |||
| 3 | G, H, K, L (A, B, C, D) | GLUTAMIC ACID | non-polymer | 147.1 | 4 | Chemie (GLU) PubChem (611) PubChem (23327) PubChem (33032) |
Sequence modifications
A, B, C, D: 1 - 908 (UniProt: P42260)
| PDB | External Database | Details |
|---|---|---|
| Cys 676 | Lys 676 | engineered mutation |
| Cys 802 | Asn 802 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 410188.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1557.6 | |
| All* | Total formula weight | 411745.7 |
