9MYF

Human malic enzyme 2 complex with inhibitor NPD-389

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	NAD-dependent malic enzyme, mitochondrial	polymer	575	64690.3	2	UniProt (P23368) Pfam (PF00390) Pfam (PF03949)	Homo sapiens (human)	NAD-ME,Malic enzyme 2
2	C, J (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
3	D, K (A, B)	2~3~,2~6~-dihydroxy-1~4~,3~4~-dimethoxy[1~1~,2~1~:2~4~,3~1~-terphenyl]-2~2~,2~5~-dione	non-polymer		352.3	2	Chemie (A1AE5)
4	E, I (A)	SUCCINIC ACID	non-polymer		118.1	2	Chemie (SIN)
5	F, G, L, M (A, B)	NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		663.4	4	Chemie (NAD)
6	H (A)	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
7	N, O (A, B)	water	water		18.0	71	Chemie (HOH)

Sequence modifications

A, B: 19 - 584 (UniProt: P23368)

PDB	External Database	Details
Met 18	-	initiating methionine
Leu 585	-	expression tag
Glu 586	-	expression tag
His 587	-	expression tag
His 588	-	expression tag
His 589	-	expression tag
His 590	-	expression tag
His 591	-	expression tag
His 592	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	129380.6
Non-Polymers*	Number of molecules	11
	Total formula weight	3738.1
All*	Total formula weight	133118.7

*Water molecules are not included.