9MY8
D7 Herpes Virus Simplex Neutralizing Nanobody Bound to HSV Glycoprotein gD
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | Anti-Nb Fab Heavy chain | polymer | 244 | 26328.1 | 1 | Lama glama (llama) | ||
| 2 | B (L) | Ig-like domain-containing protein | polymer | 214 | 23171.7 | 1 | UniProt (Q7Z3Y4) Pfam (PF07686) Pfam (PF07654) | Lama glama (llama) | |
| 3 | C (A) | D7 Neutralizing Nanobody against HSV Glycoprotein D | polymer | 125 | 13588.2 | 1 | Homo sapiens (human) | ||
| 4 | D (B) | Glycoprotein D | polymer | 327 | 36577.2 | 1 | UniProt (Q5ICU7) Pfam (PF01537) UniProt (by SIFTS) (Q69467) | Human herpesvirus 2 (HHV-2 Human herpes simplex virus 2) | |
| 5 | E, F, G, H (H, L, A, B) | water | water | 18.0 | 1489 | Chemie (HOH) |
Sequence modifications
L: 1 - 214 (UniProt: Q7Z3Y4)
B: 1 - 305 (UniProt: Q5ICU7)
| PDB | External Database | Details |
|---|---|---|
| Arg 18 | Thr 40 | conflict |
| Ser 28 | Asp 50 | conflict |
| Val 29 | Ile 51 | conflict |
| Ser 31 | Asn 53 | conflict |
| Ala 32 | Tyr 54 | conflict |
| Val 33 | Leu 55 | conflict |
| Tyr 36 | Phe 58 | conflict |
| Leu 46 | Ser 68 | conflict |
| Ser 50 | Gly 72 | conflict |
| Tyr 55 | Gln 77 | conflict |
| Pro 59 | Gln 81 | conflict |
| Arg 61 | Lys 83 | conflict |
| Arg 66 | Gly 88 | conflict |
| Ser 91 | Tyr 113 | conflict |
| Ser 92 | Lys 114 | conflict |
| Ser 94 | Tyr 116 | conflict |
| Leu 95 | Pro 117 | conflict |
| Ile 96 | Val 118 | conflict |
| Val 104 | Leu 126 | conflict |
| Ser 123 | Glu 145 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 306 | - | expression tag |
| Gly 307 | - | expression tag |
| Gly 308 | - | expression tag |
| Ser 309 | - | expression tag |
| His 310 | - | expression tag |
| His 311 | - | expression tag |
| His 312 | - | expression tag |
| His 313 | - | expression tag |
| His 314 | - | expression tag |
| His 315 | - | expression tag |
| His 316 | - | expression tag |
| His 317 | - | expression tag |
| Gly 318 | - | expression tag |
| Ser 319 | - | expression tag |
| Asp 320 | - | expression tag |
| Tyr 321 | - | expression tag |
| Lys 322 | - | expression tag |
| Asp 323 | - | expression tag |
| Asp 324 | - | expression tag |
| Asp 325 | - | expression tag |
| Asp 326 | - | expression tag |
| Lys 327 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 99665.2 | |
| All* | Total formula weight | 99665.2 |
