9MXR
Cryo-EM Structure of HIV-1 Reverse Transcriptase p66 Homodimer in Complex with 5-{2-[2-(2-oxo-4-sulfanylidene-3,4-dihydropyrimidin-1(2H)-yl)ethoxy] phenoxy}naphthalene-2-carbonitrile (JLJ648), a Non-nucleoside Inhibitor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Reverse transcriptase/ribonuclease H | polymer | 563 | 64916.3 | 2 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | Human immunodeficiency virus 1 | Exoribonuclease H,p66 RT |
| 2 | C (A) | 5-{2-[2-(2-oxo-4-sulfanylidene-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}naphthalene-2-carbonitrile | non-polymer | 415.5 | 1 | Chemie (A1BTU) |
Sequence modifications
A, B: 1 - 555 (UniProt: P03366)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| Val 0 | - | expression tag |
| Glu 556 | - | expression tag |
| Asn 557 | - | expression tag |
| Leu 558 | - | expression tag |
| Tyr 559 | - | expression tag |
| Phe 560 | - | expression tag |
| Gln 561 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 129832.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 415.5 | |
| All* | Total formula weight | 130248.2 |
