9MWU
Structure of human endothelial nitric oxide synthase heme domain bound with N-(3-(((2-(3-(aminomethyl)-[1,1'-biphenyl]-4-yl)ethyl)amino)methyl)phenyl)furan-2-carboximidamide
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Nitric oxide synthase 3 | polymer | 441 | 49474.9 | 2 | UniProt (P29474) Pfam (PF02898) | Homo sapiens (human) | Constitutive NOS,cNOS,EC-NOS,NOS type III,NOSIII,Nitric oxide synthase,endothelial,Endothelial NOS,eNOS |
| 2 | C, O (A, B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 3 | D, P (A, B) | 5,6,7,8-TETRAHYDROBIOPTERIN | non-polymer | 241.2 | 2 | Chemie (H4B) | |||
| 4 | E, Q (A, B) | N-{3-[({2-[3-(aminomethyl)[1,1'-biphenyl]-4-yl]ethyl}amino)methyl]phenyl}furan-2-carboximidamide | non-polymer | 424.5 | 2 | Chemie (A1BT2) | |||
| 5 | F, G, R (A, B) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 6 | H, I, J, S, T (A, B) | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 209.2 | 5 | Chemie (BTB) | |||
| 7 | K, U, V (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 8 | L, W (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 9 | M, X (A, B) | GADOLINIUM ATOM | non-polymer | 157.3 | 2 | Chemie (GD) | |||
| 10 | N (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 11 | Y, Z (A, B) | water | water | 18.0 | 881 | Chemie (HOH) |
Sequence modifications
A, B: 41 - 481 (UniProt: P29474)
| PDB | External Database | Details |
|---|---|---|
| Glu 298 | Asp 298 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 98949.9 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 4515.0 | |
| All* | Total formula weight | 103464.9 |
