9MWP
Structure of human endothelial nitric oxide synthase heme domain bound with N-(4-(2-((3-(furan-3-carboximidamido)benzyl)amino)ethyl)phenyl)furan-3-carboximidamide
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Nitric oxide synthase 3 | polymer | 441 | 49474.9 | 2 | UniProt (P29474) Pfam (PF02898) | Homo sapiens (human) | Constitutive NOS,cNOS,EC-NOS,NOS type III,NOSIII,Nitric oxide synthase,endothelial,Endothelial NOS,eNOS |
| 2 | C, O (A, B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 3 | D, P (A, B) | 5,6,7,8-TETRAHYDROBIOPTERIN | non-polymer | 241.2 | 2 | Chemie (H4B) | |||
| 4 | E, Q (A, B) | N-[3-({[2-(4-{[(E)-(furan-3-yl)(imino)methyl]amino}phenyl)ethyl]amino}methyl)phenyl]furan-3-carboximidamide | non-polymer | 427.5 | 2 | Chemie (A1BT1) | |||
| 5 | F, G, R, S (A, B) | ACETATE ION | non-polymer | 59.0 | 4 | Chemie (ACT) | |||
| 6 | H, I, J, T, U (A, B) | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 209.2 | 5 | Chemie (BTB) | |||
| 7 | K, L, V, W, X (A, B) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 8 | M, Y (A, B) | GADOLINIUM ATOM | non-polymer | 157.3 | 2 | Chemie (GD) | |||
| 9 | N (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 10 | AA, Z (B, A) | water | water | 18.0 | 730 | Chemie (HOH) |
Sequence modifications
A, B: 41 - 481 (UniProt: P29474)
| PDB | External Database | Details |
|---|---|---|
| Glu 298 | Asp 298 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 98949.9 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 4693.2 | |
| All* | Total formula weight | 103643.1 |
