9MVX
Crystal structure of knob-in-hole immunoglobulin G1 Fc heterodimer with P374A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform 1 of Immunoglobulin heavy constant gamma 1 HC1 (Hole) | polymer | 223 | 24985.2 | 1 | UniProt (P01857) Pfam (PF07654) | Homo sapiens (human) | Ig gamma-1 chain C region,Ig gamma-1 chain C region EU,Ig gamma-1 chain C region KOL,Ig gamma-1 chain C region NIE |
| 2 | B (B) | Isoform 1 of Immunoglobulin heavy constant gamma 1 HC2 (Knob) | polymer | 223 | 25188.6 | 1 | UniProt (P01857) Pfam (PF07654) | Homo sapiens (human) | Ig gamma-1 chain C region,Ig gamma-1 chain C region EU,Ig gamma-1 chain C region KOL,Ig gamma-1 chain C region NIE |
| 3 | C (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1317.2 | 1 | In PDB GlyTouCan (G39213VZ) | |||
| 4 | D (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1463.3 | 1 | In PDB GlyTouCan (G80858MF) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 296 | Chemie (HOH) |
Sequence modifications
A: 225 - 447 (UniProt: P01857)
B: 225 - 447 (UniProt: P01857)
| PDB | External Database | Details |
|---|---|---|
| Asp 253 | Ile 136 | engineered mutation |
| Glu 356 | Asp 239 | conflict |
| Met 358 | Leu 241 | conflict |
| Ser 366 | Thr 249 | engineered mutation |
| Ala 368 | Leu 251 | engineered mutation |
| Ala 374 | Pro 257 | engineered mutation |
| Val 407 | Tyr 290 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Glu 356 | Asp 239 | conflict |
| Met 358 | Leu 241 | conflict |
| Trp 366 | Thr 249 | engineered mutation |
| Ala 374 | Pro 257 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 50173.8 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 2780.6 | |
| All* | Total formula weight | 52954.4 |
