9MUL
Crystal structure of GluN1/GluN2A ligand-binding domain in complex with Compound 1, Glycine and Glutamate
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glutamate receptor ionotropic, NMDA 1 | polymer | 306 | 35164.0 | 1 | UniProt (Q05586) Pfam (PF10613) Pfam (PF00060) | Homo sapiens (human) | GluN1,Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1,hNR1 |
| 2 | B (B) | Glutamate receptor ionotropic, NMDA 2A | polymer | 297 | 33551.3 | 1 | UniProt (Q12879) Pfam (PF10613) Pfam (PF00060) | Homo sapiens (human) | GluN2A,Glutamate [NMDA] receptor subunit epsilon-1,N-methyl D-aspartate receptor subtype 2A,NMDAR2A,NR2A,hNR2A |
| 3 | C (A) | GLYCINE | non-polymer | 75.1 | 1 | Chemie (GLY) | |||
| 4 | D (B) | GLUTAMIC ACID | non-polymer | 147.1 | 1 | Chemie (GLU) | |||
| 5 | E (B) | 5-[(3-chlorobenzene-1-sulfonyl)methoxy]-6-methyl-N-[(pyridin-3-yl)methyl]pyrazine-2-carboxamide | non-polymer | 432.9 | 1 | Chemie (A1BRA) | |||
| 6 | F, G (A, B) | water | water | 18.0 | 252 | Chemie (HOH) |
Sequence modifications
A: 394 - 544 (UniProt: Q05586)
A: 663 - 800 (UniProt: Q05586)
B: 401 - 539 (UniProt: Q12879)
B: 542 - 802 (UniProt: Q12879)
| PDB | External Database | Details |
|---|---|---|
| Met 379 | - | initiating methionine |
| His 380 | - | expression tag |
| His 381 | - | expression tag |
| His 382 | - | expression tag |
| His 383 | - | expression tag |
| His 384 | - | expression tag |
| His 385 | - | expression tag |
| Glu 386 | - | expression tag |
| Asn 387 | - | expression tag |
| Leu 388 | - | expression tag |
| Tyr 389 | - | expression tag |
| Phe 390 | - | expression tag |
| Gln 391 | - | expression tag |
| Gly 392 | - | expression tag |
| Ser 393 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 545 | - | linker |
| Thr 546 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Met 387 | - | initiating methionine |
| His 388 | - | expression tag |
| His 389 | - | expression tag |
| His 390 | - | expression tag |
| His 391 | - | expression tag |
| His 392 | - | expression tag |
| His 393 | - | expression tag |
| Glu 394 | - | expression tag |
| Asn 395 | - | expression tag |
| Leu 396 | - | expression tag |
| Tyr 397 | - | expression tag |
| Phe 398 | - | expression tag |
| Gln 399 | - | expression tag |
| Gly 400 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 540 | - | linker |
| Thr 541 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68715.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 655.1 | |
| All* | Total formula weight | 69370.3 |
