9MSP

Crystal structure of MPXV A35R in complex with neutralizing antibody EV35-7

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, E, F (E, F, A, B)	Protein OPG161	polymer	100	11414.2	4	UniProt (A0A7H0DND2) Pfam (PF05966)	Monkeypox virus
2	C, G (H, C)	EV35-7 heavy chain	polymer	225	24098.1	2		Homo sapiens
3	D, H (L, D)	EV35-7 light chain	polymer	212	23171.7	2		Homo sapiens
4	I (E)	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
5	J, L (F, A)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
6	K, M, N (L, C, D)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
7	O, P, Q, R, S... (E, F, H, L, A...)	water	water		18.0	457	Chemie (HOH)

Sequence modifications

E, F, A, B: 90 - 181 (UniProt: A0A7H0DND2)

PDB	External Database	Details
Gly 182	-	expression tag
Ser 183	-	expression tag
His 184	-	expression tag
His 185	-	expression tag
His 186	-	expression tag
His 187	-	expression tag
His 188	-	expression tag
His 189	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	140196.4
Non-Polymers*	Number of molecules	6
	Total formula weight	471.4
All*	Total formula weight	140667.7

*Water molecules are not included.