9MRS
Crystal structure of human MMACHC in complex with MMADHC and B12
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, D, F (A, B, E, G) | Cyanocobalamin reductase / alkylcobalamin dealkylase | polymer | 223 | 25698.5 | 4 | UniProt (Q9Y4U1) Pfam (PF16690) | Homo sapiens (human) | Alkylcobalamin:glutathione S-alkyltransferase,CblC,Cyanocobalamin reductase (cyanide-eliminating),Methylmalonic aciduria and homocystinuria type C protein,MMACHC |
| 2 | B, E, G, H (D, F, C, H) | Cobalamin trafficking protein CblD | polymer | 296 | 32959.1 | 4 | UniProt (Q9H3L0) Pfam (PF10229) | Homo sapiens (human) | CblD,Methylmalonic aciduria and homocystinuria type D protein,mitochondrial |
| 3 | I, J, K, L (A, B, E, G) | COBALAMIN | non-polymer | 1330.4 | 4 | Chemie (B12) |
Sequence modifications
D, F, C, H: 1 - 296 (UniProt: Q9H3L0)
| PDB | External Database | Details |
|---|---|---|
| Ser 262 | Cys 262 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 234630.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 5321.4 | |
| All* | Total formula weight | 239951.6 |
