9MR9
Crystal structure of AU-15330 in complex with the bromodomain of human BRM (SMARCA2) and pVHL:ElonginC:ElonginB
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, CA, E, I, M... (A, E, I, M, Q...) | Isoform Short of Probable global transcription activator SNF2L2 | polymer | 122 | 14249.3 | 8 | UniProt (P51531) Pfam (PF00439) | Homo sapiens (human) | ATP-dependent helicase SMARCA2,BRG1-associated factor 190B,BAF190B,Protein brahma homolog,hBRM,SNF2-alpha,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 |
| 2 | B, DA, F, J, N... (B, F, J, N, R...) | von Hippel-Lindau disease tumor suppressor | polymer | 161 | 18615.2 | 8 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | Homo sapiens (human) | Protein G7,pVHL |
| 3 | AA, C, EA, G, K... (C, G, K, O, S...) | Elongin-C | polymer | 96 | 10843.4 | 8 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 4 | BA, D, FA, H, L... (D, H, L, P, T...) | Elongin-B | polymer | 104 | 11748.4 | 8 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 5 | GA, IA, LA, OA, PA... (B, F, J, N, Q...) | N-({4-[(6M)-3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl}acetyl)-3-methyl-L-valyl-(4R)-4-hydroxy-N-{(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl}-L-prolinamide | non-polymer | 755.9 | 8 | Chemie (A1BNT) PubChem (156168451) PubChem (166643438) PubChem (166718167) PubChem (156113155) PubChem (156164611) PubChem (166643440) PubChem (166718201) PubChem (168310513) | |||
| 6 | HA, JA, KA, NA, QA... (B, F, J, R, c) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 7 | MA (J) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 8 | AB, BB, CB, DB, EB... (F, G, H, I, J...) | water | water | 18.0 | 107 | Chemie (HOH) |
Sequence modifications
A, E, I, M, Q, U, Y, c: 1373 - 1493 (UniProt: P51531)
B, F, J, N, R, V, Z, d: 54 - 213 (UniProt: P40337)
| PDB | External Database | Details |
|---|---|---|
| Ser 1372 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 53 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 32 |
| Total formula weight | 443651.1 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 6511.9 | |
| All* | Total formula weight | 450163.0 |
