9MR5

Cryo-EM structure of human OATP1C1 F240A mutant in complex with estrone 3-glucuronide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Solute carrier organic anion transporter family member 1C1	polymer	746	82463.2	1	UniProt (Q9NYB5) Pfam (PF03137) Pfam (PF07648)	Homo sapiens (human)	Organic anion transporter 1C1,OATP1C1,Organic anion transporter F,OATP-F,Organic anion transporter polypeptide-related protein 5,OAT-RP-5,OATP-RP5,Organic anion-transporting polypeptide 14,OATP-14,Solute carrier family 21 member 14,Thyroxine transporter
2	B (A)	ESTRONE BETA-D-GLUCURONIDE	non-polymer		446.5	1	Chemie (E3G)

Sequence modifications

A: 1 - 712 (UniProt: Q9NYB5)

PDB	External Database	Details
Ala 240	Phe 240	engineered mutation
Ala 713	-	expression tag
Ala 714	-	expression tag
Ala 715	-	expression tag
Leu 716	-	expression tag
Glu 717	-	expression tag
Val 718	-	expression tag
Leu 719	-	expression tag
Phe 720	-	expression tag
Gln 721	-	expression tag
Gly 722	-	expression tag
Pro 723	-	expression tag
Gly 724	-	expression tag
Ala 725	-	expression tag
Ala 726	-	expression tag
Glu 727	-	expression tag
Asp 728	-	expression tag
Gln 729	-	expression tag
Val 730	-	expression tag
Asp 731	-	expression tag
Pro 732	-	expression tag
Arg 733	-	expression tag
Leu 734	-	expression tag
Ile 735	-	expression tag
Asp 736	-	expression tag
Gly 737	-	expression tag
Lys 738	-	expression tag
His 739	-	expression tag
His 740	-	expression tag
His 741	-	expression tag
His 742	-	expression tag
His 743	-	expression tag
His 744	-	expression tag
His 745	-	expression tag
His 746	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	82463.2
Non-Polymers*	Number of molecules	1
	Total formula weight	446.5
All*	Total formula weight	82909.7

*Water molecules are not included.