9MQ5
Crystal structure SHP2 tandem SH2 domains in complex with PZR doubly tyrosine phosphorylated ITIM peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein phosphatase non-receptor type 11 | polymer | 225 | 25230.4 | 1 | UniProt (Q06124) Pfam (PF00017) | Homo sapiens (human) | Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,SHP-2,Shp2,SH-PTP3 |
| 2 | B (B) | Myelin protein zero-like protein 1 | polymer | 33 | 3803.0 | 1 | UniProt (O95297) | Homo sapiens | Protein zero-related |
| 3 | C, D, E, F, G... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 4 | J, K (A, B) | water | water | 18.0 | 145 | Chemie (HOH) |
Sequence modifications
A: 1 - 220 (UniProt: Q06124)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Leu -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29033.3 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 434.5 | |
| All* | Total formula weight | 29467.8 |
