9MQ2
Cryo-EM map of H5 HA (A/Jiangsu/NJ210/2023) in complex with monoclonal fab 12G1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Hemagglutinin HA1 | polymer | 345 | 39088.6 | 3 | UniProt (A0A8E4ZAK5) | Influenza A virus | |
| 2 | D (H) | 12G1 Heavy Chain Fab | polymer | 122 | 13480.0 | 1 | Homo sapiens | ||
| 3 | E (L) | 12G1 Light Chain Fab | polymer | 111 | 12116.6 | 1 | Homo sapiens | ||
| 4 | F, G, H (a, b, c) | Hemagglutinin HA2 | polymer | 220 | 25352.9 | 3 | UniProt (A0AAX6NNL9) | Influenza A virus | |
| 5 | I, J, K (D, E, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 3 | In PDB GlyTouCan (G21290RB) | |||
| 6 | L, M, N, O, P... (A, B, C, a, c) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 11 | Chemie (NAG) |
Sequence modifications
A, B, C: -5 - 332 (UniProt: A0A8E4ZAK5)
a, b, c: 1 - 176 (UniProt: A0AAX6NNL9)
| PDB | External Database | Details |
|---|---|---|
| Asn 6 | Ser 12 | conflict |
| Asp 91 | Ala 99 | conflict |
| Asp 158 | Asn 170 | conflict |
| Pro 325 | Leu 338 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 177 | - | expression tag |
| Tyr 178 | - | expression tag |
| Ile 179 | - | expression tag |
| Pro 180 | - | expression tag |
| Glu 181 | - | expression tag |
| Ala 182 | - | expression tag |
| Pro 183 | - | expression tag |
| Arg 184 | - | expression tag |
| Asp 185 | - | expression tag |
| Gly 186 | - | expression tag |
| Gln 187 | - | expression tag |
| Ala 188 | - | expression tag |
| Tyr 189 | - | expression tag |
| Val 190 | - | expression tag |
| Arg 191 | - | expression tag |
| Lys 192 | - | expression tag |
| Asp 193 | - | expression tag |
| Gly 194 | - | expression tag |
| Glu 195 | - | expression tag |
| Trp 196 | - | expression tag |
| Val 197 | - | expression tag |
| Leu 198 | - | expression tag |
| Leu 199 | - | expression tag |
| Ser 200 | - | expression tag |
| Thr 201 | - | expression tag |
| Phe 202 | - | expression tag |
| Leu 203 | - | expression tag |
| Gly 204 | - | expression tag |
| Ser 205 | - | expression tag |
| Glu 206 | - | expression tag |
| Asn 207 | - | expression tag |
| Leu 208 | - | expression tag |
| Tyr 209 | - | expression tag |
| Phe 210 | - | expression tag |
| Gln 211 | - | expression tag |
| Gly 212 | - | expression tag |
| Gly 213 | - | expression tag |
| Ser 214 | - | expression tag |
| His 215 | - | expression tag |
| His 216 | - | expression tag |
| His 217 | - | expression tag |
| His 218 | - | expression tag |
| His 219 | - | expression tag |
| His 220 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 218921.3 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1711.6 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2433.3 | |
| All* | Total formula weight | 223066.2 |
