9MOV
Cryo-EM structure of factor Va bound to activated protein C
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Coagulation factor Va heavy chain | polymer | 709 | 81274.4 | 1 | UniProt (P12259) Pfam (PF07732) | Homo sapiens (human) | Activated protein C cofactor,Proaccelerin,labile factor |
| 2 | B (B) | Coagulation factor Va light chain | polymer | 651 | 75283.0 | 1 | UniProt (P12259) Pfam (PF07732) Pfam (PF00754) | Homo sapiens (human) | Activated protein C cofactor,Proaccelerin,labile factor |
| 3 | C (C) | Vitamin K-dependent protein C | polymer | 146 | 16832.6 | 1 | UniProt (P04070) Pfam (PF00594) Pfam (PF14670) | Homo sapiens (human) | Anticoagulant protein C,Autoprothrombin IIA,Blood coagulation factor XIV |
| 4 | D (D) | Vitamin K-dependent protein C heavy chain | polymer | 240 | 26949.8 | 1 | UniProt (P04070) Pfam (PF00089) | Homo sapiens (human) | |
| 5 | E, F, G, H, I... (A, B, C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 9 | Chemie (NAG) | |||
| 6 | K, L, M, N, O... (C) | CALCIUM ION | non-polymer | 40.1 | 7 | Chemie (CA) |
Sequence modifications
D: 170 - 409 (UniProt: P04070)
| PDB | External Database | Details |
|---|---|---|
| Ala 360 | Ser 402 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 200339.9 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2271.4 | |
| All* | Total formula weight | 202611.3 |
