9MOT
Cryo-EM structure of factor Va bound to activated protein C
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Coagulation factor Va heavy chain | polymer | 709 | 81274.4 | 1 | UniProt (P12259) Pfam (PF07732) | Homo sapiens (human) | Activated protein C cofactor,Proaccelerin,labile factor |
| 2 | B (B) | Coagulation factor Va light chain | polymer | 651 | 75283.0 | 1 | UniProt (P12259) Pfam (PF07732) Pfam (PF00754) | Homo sapiens (human) | Activated protein C cofactor,Proaccelerin,labile factor |
| 3 | C (D) | Vitamin K-dependent protein C heavy chain | polymer | 240 | 26949.8 | 1 | UniProt (P04070) Pfam (PF00089) | Homo sapiens (human) | |
| 4 | D, E, F, G, H... (A, B, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) |
Sequence modifications
D: 170 - 409 (UniProt: P04070)
| PDB | External Database | Details |
|---|---|---|
| Ala 360 | Ser 402 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 183507.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1769.7 | |
| All* | Total formula weight | 185276.9 |
