9MOE
Preclinical and clinical evaluation of a novel TRPA1 antagonist LY3526318
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, D, E) | Transient receptor potential cation channel subfamily A member 1 | polymer | 1120 | 127699.6 | 4 | UniProt (O75762) Pfam (PF00023) Pfam (PF00520) | Homo sapiens (human) | Ankyrin-like with transmembrane domains protein 1,Transformation-sensitive protein p120,p120,Wasabi receptor |
| 2 | E, F, G, H (A, B, D, E) | (2S)-2-{3-methyl-1-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl}-N-{6-[2-(trifluoromethyl)pyrimidin-5-yl]pyridin-2-yl}propanamide | non-polymer | 556.5 | 4 | Chemie (A1BNO) |
Sequence modifications
A, B, D, E: 2 - 1119 (UniProt: O75762)
| PDB | External Database | Details |
|---|---|---|
| Leu 0 | - | expression tag |
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 510798.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2225.8 | |
| All* | Total formula weight | 513024.2 |
