9MNY
Cryo-EM structure of human MPC with pyruvate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitochondrial pyruvate carrier 1 | polymer | 115 | 13094.4 | 1 | UniProt (Q9Y5U8) Pfam (PF03650) | Homo sapiens (human) | Brain protein 44-like protein |
| 2 | B (B) | Mitochondrial pyruvate carrier 2 | polymer | 127 | 14386.0 | 1 | UniProt (O95563) Pfam (PF03650) | Homo sapiens (human) | Brain protein 44 |
| 3 | C (D) | Fab_8D3_2 heavy chain | polymer | 265 | 28833.3 | 1 | Mus musculus (mouse) | ||
| 4 | D (E) | Fab_8D3_2 light chain | polymer | 247 | 27359.7 | 1 | Mus musculus (mouse) | ||
| 5 | E (C) | Nanobody | polymer | 152 | 16690.8 | 1 | synthetic construct | ||
| 6 | F (F) | MBP-PrA/G | polymer | 545 | 59233.2 | 1 | Escherichia coli | ||
| 7 | G (B) | PYRUVIC ACID | non-polymer | 88.1 | 1 | Chemie (PYR) |
Sequence modifications
A: 1 - 109 (UniProt: Q9Y5U8)
B: 1 - 127 (UniProt: O95563)
| PDB | External Database | Details |
|---|---|---|
| Leu 110 | - | expression tag |
| Glu 111 | - | expression tag |
| Val 112 | - | expression tag |
| Leu 113 | - | expression tag |
| Phe 114 | - | expression tag |
| Gln 115 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Trp 74 | Val 74 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 159597.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 88.1 | |
| All* | Total formula weight | 159685.5 |
