9MNC

Human 80S ribosome bound to small molecule SW393071

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (L1)	5.8S rRNA	polymer	157	50463.8	1	GenBank (555853)	Homo sapiens (human)
2	B (L5)	28S rRNA	polymer	5069	1640938.6	1		Homo sapiens (human)
3	C (L8)	Large ribosomal subunit protein uL18	polymer	297	34426.8	1	UniProt (P46777) Pfam (PF17144) Pfam (PF14204)	Homo sapiens (human)	60S ribosomal protein L5
4	D (L9)	5S rRNA	polymer	121	38998.1	1	GenBank (23898)	Homo sapiens (human)
5	E (LB)	Large ribosomal subunit protein uL3	polymer	403	46224.1	1	UniProt (P39023) Pfam (PF00297)	Homo sapiens (human)	60S ribosomal protein L3, HIV-1 TAR RNA-binding protein B,TARBP-B
6	F (LC)	Large ribosomal subunit protein uL4	polymer	427	47804.6	1	UniProt (P36578) Pfam (PF00573) Pfam (PF14374)	Homo sapiens (human)	60S ribosomal protein L4, 60S ribosomal protein L1
7	G (LD)	Large ribosomal subunit protein uL2	polymer	257	28103.9	1	UniProt (P62917) Pfam (PF00181) Pfam (PF03947)	Homo sapiens (human)	60S ribosomal protein L8
8	H (LE)	Large ribosomal subunit protein uL24	polymer	145	17303.4	1	UniProt (P61254) Pfam (PF16906) Pfam (PF00467)	Homo sapiens (human)	60S ribosomal protein L26
9	I (LF)	Large ribosomal subunit protein uL30	polymer	248	29307.0	1	UniProt (P18124) Pfam (PF08079) Pfam (PF00327)	Homo sapiens (human)	60S ribosomal protein L7
10	J (LG)	Large ribosomal subunit protein eL8	polymer	266	30061.8	1	UniProt (P62424) Pfam (PF01248)	Homo sapiens (human)	60S ribosomal protein L7a,PLA-X polypeptide,Surfeit locus protein 3
11	K (LH)	Large ribosomal subunit protein uL6	polymer	192	21899.5	1	UniProt (P32969) Pfam (PF00347)	Homo sapiens (human)	60S ribosomal protein L9
12	L (LI)	Large ribosomal subunit protein eL32	polymer	135	15898.9	1	UniProt (P62910) Pfam (PF01655)	Homo sapiens (human)	60S ribosomal protein L32
13	M (LJ)	Large ribosomal subunit protein uL5	polymer	178	20288.5	1	UniProt (P62913) Pfam (PF00281) Pfam (PF00673)	Homo sapiens (human)	60S ribosomal protein L11, CLL-associated antigen KW-12
14	N (LK)	Large ribosomal subunit protein eL6	polymer	288	32810.2	1	UniProt (Q02878) Pfam (PF03868) Pfam (PF01159)	Homo sapiens (human)	60S ribosomal protein L6,Neoplasm-related protein C140,Tax-responsive enhancer element-binding protein 107,TaxREB107
15	O (LM)	Large ribosomal subunit protein eL14	polymer	215	23485.0	1	UniProt (P50914) Pfam (PF01929)	Homo sapiens (human)	60S ribosomal protein L14,CAG-ISL 7
16	P (LN)	Large ribosomal subunit protein eL15	polymer	204	24207.3	1	UniProt (P61313) Pfam (PF00827)	Homo sapiens (human)	60S ribosomal protein L15
17	Q (LO)	Large ribosomal subunit protein uL29	polymer	123	14593.6	1	UniProt (P42766) Pfam (PF00831)	Homo sapiens (human)	60S ribosomal protein L35
18	R (LP)	Large ribosomal subunit protein eL37	polymer	97	11111.0	1	UniProt (P61927) Pfam (PF01907)	Homo sapiens (human)	60S ribosomal protein L37,G1.16
19	S (LQ)	Large ribosomal subunit protein eL13	polymer	211	24321.7	1	UniProt (P26373) Pfam (PF01294)	Homo sapiens (human)	60S ribosomal protein L13,Breast basic conserved protein 1
20	T (LR)	Large ribosomal subunit protein eL19	polymer	196	23535.3	1	UniProt (P84098) Pfam (PF01280) Pfam (PF25476)	Homo sapiens (human)	60S ribosomal protein L19
21	U (LS)	Large ribosomal subunit protein eL20	polymer	176	20808.5	1	UniProt (Q02543) Pfam (PF01775)	Homo sapiens (human)	60S ribosomal protein L18a
22	V (LT)	Large ribosomal subunit protein eL21	polymer	160	18610.0	1	UniProt (P46778) Pfam (PF01157)	Homo sapiens (human)	60S ribosomal protein L21
23	W (LU)	Large ribosomal subunit protein eL39	polymer	51	6426.8	1	UniProt (P62891) Pfam (PF00832)	Homo sapiens (human)	60S ribosomal protein L39
24	X (LV)	Large ribosomal subunit protein uL14	polymer	140	14892.5	1	UniProt (P62829) Pfam (PF00238)	Homo sapiens (human)	60S ribosomal protein L23,60S ribosomal protein L17
25	Y (LW)	Large ribosomal subunit protein eL24	polymer	157	17825.1	1	UniProt (P83731) Pfam (PF01246)	Homo sapiens (human)	60S ribosomal protein L24,60S ribosomal protein L30
26	Z (LY)	Large ribosomal subunit protein uL13	polymer	203	23633.4	1	UniProt (P40429) Pfam (PF00572)	Homo sapiens (human)	60S ribosomal protein L13a,23 kDa highly basic protein
27	AA (LZ)	Large ribosomal subunit protein eL27	polymer	136	15835.8	1	UniProt (P61353) Pfam (PF00467) Pfam (PF01777)	Homo sapiens (human)	60S ribosomal protein L27
28	BA (La)	Large ribosomal subunit protein uL15	polymer	148	16619.5	1	UniProt (P46776) Pfam (PF00828)	Homo sapiens (human)	60S ribosomal protein L27a
29	CA (Lb)	Large ribosomal subunit protein eL29	polymer	161	18017.6	1	UniProt (Q6IPI1)	Homo sapiens (human)
30	DA (Lc)	Large ribosomal subunit protein eL30	polymer	115	12805.1	1	UniProt (P62888) Pfam (PF01248)	Homo sapiens (human)	60S ribosomal protein L30
31	EA (Ld)	Large ribosomal subunit protein eL31	polymer	125	14494.9	1	UniProt (P62899) Pfam (PF01198)	Homo sapiens (human)	60S ribosomal protein L31
32	FA (Le)	Large ribosomal subunit protein eL42	polymer	106	12490.0	1	UniProt (P83881) Pfam (PF00935)	Homo sapiens (human)	60S ribosomal protein L36a,60S ribosomal protein L44,Cell growth-inhibiting gene 15 protein,Cell migration-inducing gene 6 protein
33	GA (Lf)	Large ribosomal subunit protein eL33	polymer	110	12564.7	1	UniProt (P18077) Pfam (PF01247)	Homo sapiens (human)	60S ribosomal protein L35a,Cell growth-inhibiting gene 33 protein
34	HA (Lg)	Large ribosomal subunit protein eL34	polymer	117	13326.1	1	UniProt (P49207) Pfam (PF01199)	Homo sapiens (human)	60S ribosomal protein L34
35	IA (Lh)	Large ribosomal subunit protein uL22	polymer	184	21443.2	1	UniProt (P18621) Pfam (PF00237)	Homo sapiens (human)	60S ribosomal protein L17,60S ribosomal protein L23,PD-1
36	JA (Li)	Large ribosomal subunit protein eL36	polymer	105	12290.9	1	UniProt (Q9Y3U8) Pfam (PF01158)	Homo sapiens (human)	60S ribosomal protein L36
37	KA (Lj)	Large ribosomal subunit protein eL18	polymer	188	21687.7	1	UniProt (Q07020) Pfam (PF17135)	Homo sapiens (human)	60S ribosomal protein L18
38	LA (Lk)	Large ribosomal subunit protein eL38	polymer	70	8238.9	1	UniProt (P63173) Pfam (PF01781)	Homo sapiens (human)	60S ribosomal protein L38
39	MA (Ll)	Large ribosomal subunit protein eL28	polymer	137	15679.5	1	UniProt (P46779) Pfam (PF01778)	Homo sapiens (human)	60S ribosomal protein L28
40	NA (Lm)	Large ribosomal subunit protein eL22	polymer	128	14813.0	1	UniProt (P35268) Pfam (PF01776)	Homo sapiens (human)	60S ribosomal protein L22,EBER-associated protein,EAP,Epstein-Barr virus small RNA-associated protein,Heparin-binding protein HBp15
41	OA (Ln)	Large ribosomal subunit protein uL23	polymer	156	17740.2	1	UniProt (P62750) Pfam (PF03939) Pfam (PF00276)	Homo sapiens (human)	60S ribosomal protein L23a
42	PA (Lo)	Large ribosomal subunit protein eL40	polymer	99	11512.8	1	UniProt (P62987) Pfam (PF00240) Pfam (PF01020)	Homo sapiens (human)	60S ribosomal protein L40
43	QA (Lp)	Large ribosomal subunit protein eL43	polymer	92	10299.4	1	UniProt (P61513) Pfam (PF01780)	Homo sapiens (human)	60S ribosomal protein L37a
44	RA (Lz)	Large ribosomal subunit protein uL16	polymer	214	24630.1	1	UniProt (P27635) Pfam (PF00252)	Homo sapiens (human)	60S ribosomal protein L10,Laminin receptor homolog,Protein QM,Ribosomal protein L10,Tumor suppressor QM
45	SA (S1)	Small ribosomal subunit protein eS1	polymer	264	30002.1	1	UniProt (P61247) Pfam (PF01015)	Homo sapiens (human)	40S ribosomal protein S3a,v-fos transformation effector protein,Fte-1
46	TA (SA)	Small ribosomal subunit protein uS2	polymer	295	32778.8	1	UniProt (P08865) Pfam (PF00318) Pfam (PF16122)	Homo sapiens (human)	37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,40S ribosomal protein SA,67 kDa laminin receptor,67LR,Colon carcinoma laminin-binding protein,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40,Multidrug resistance-associated protein MGr1-Ag,NEM/1CHD4
47	UA (SC)	Small ribosomal subunit protein uS5	polymer	293	31376.5	1	UniProt (P15880) Pfam (PF00333) Pfam (PF03719)	Homo sapiens (human)	40S ribosomal protein S2,40S ribosomal protein S4,Protein LLRep3
48	VA (SD)	Small ribosomal subunit protein uS7	polymer	204	22913.5	1	UniProt (P46782) Pfam (PF00177)	Homo sapiens (human)	40S ribosomal protein S5
49	WA (SE)	Small ribosomal subunit protein eS4, X isoform	polymer	263	29654.9	1	UniProt (P62701) Pfam (PF08071) Pfam (PF00900) Pfam (PF00467) Pfam (PF16121)	Homo sapiens (human)	40S ribosomal protein S4,SCR10,Single copy abundant mRNA protein
50	XA (SG)	Small ribosomal subunit protein eS6	polymer	249	28751.9	1	UniProt (P62753) Pfam (PF01092)	Homo sapiens (human)	40S ribosomal protein S6,Phosphoprotein NP33
51	YA (SH)	Small ribosomal subunit protein eS7	polymer	194	22168.9	1	UniProt (P62081) Pfam (PF01251)	Homo sapiens (human)	40S ribosomal protein S7
52	ZA (SI)	Small ribosomal subunit protein eS8	polymer	208	24263.4	1	UniProt (P62241) Pfam (PF01201)	Homo sapiens (human)	40S ribosomal protein S8
53	AB (SJ)	Small ribosomal subunit protein uS4	polymer	194	22641.6	1	UniProt (P46781) Pfam (PF00163) Pfam (PF01479)	Homo sapiens (human)	40S ribosomal protein S9
54	BB (SK)	Small ribosomal subunit protein uS3	polymer	243	26729.4	1	UniProt (P23396) Pfam (PF07650) Pfam (PF00189)	Homo sapiens (human)	40S ribosomal protein S3
55	CB (SL)	Small ribosomal subunit protein uS17	polymer	158	18468.8	1	UniProt (P62280) Pfam (PF16205) Pfam (PF00366)	Homo sapiens (human)	40S ribosomal protein S11
56	DB (SM)	Small ribosomal subunit protein eS10	polymer	165	18933.8	1	UniProt (P46783) Pfam (PF03501)	Homo sapiens (human)	40S ribosomal protein S10
57	EB (SN)	Small ribosomal subunit protein uS15	polymer	151	17259.4	1	UniProt (P62277) Pfam (PF08069) Pfam (PF00312)	Homo sapiens (human)	40S ribosomal protein S13
58	FB (SO)	Small ribosomal subunit protein uS11	polymer	151	16302.8	1	UniProt (P62263) Pfam (PF00411)	Homo sapiens (human)	40S ribosomal protein S14
59	GB (SP)	Small ribosomal subunit protein uS19	polymer	145	17076.2	1	UniProt (P62841) Pfam (PF00203)	Homo sapiens (human)	40S ribosomal protein S15,RIG protein
60	HB (SQ)	Small ribosomal subunit protein uS9	polymer	146	16477.4	1	UniProt (P62249) Pfam (PF00380)	Homo sapiens (human)	40S ribosomal protein S16
61	IB (SS)	Small ribosomal subunit protein eS17	polymer	135	15578.2	1	UniProt (P08708) Pfam (PF00833)	Homo sapiens (human)	40S ribosomal protein S17
62	JB (ST)	Small ribosomal subunit protein uS13	polymer	152	17759.8	1	UniProt (P62269) Pfam (PF00416)	Homo sapiens (human)	40S ribosomal protein S18,Ke-3,Ke3
63	KB (SU)	Small ribosomal subunit protein eS19	polymer	145	16091.6	1	UniProt (P39019) Pfam (PF01090)	Homo sapiens (human)	40S ribosomal protein S19
64	LB (SV)	Small ribosomal subunit protein eS21	polymer	83	9124.4	1	UniProt (P63220) Pfam (PF01249)	Homo sapiens (human)	40S ribosomal protein S21
65	MB (SW)	Small ribosomal subunit protein uS8	polymer	130	14865.6	1	UniProt (P62244) Pfam (PF00410)	Homo sapiens (human)	40S ribosomal protein S15a
66	NB (SX)	Small ribosomal subunit protein uS12	polymer	143	15860.7	1	UniProt (P62266) Pfam (PF00164)	Homo sapiens (human)	40S ribosomal protein S23
67	OB (SY)	Isoform 3 of Small ribosomal subunit protein eS24	polymer	132	15366.3	1	UniProt (P62847) Pfam (PF01282)	Homo sapiens (human)	40S ribosomal protein S24
68	PB (SZ)	Small ribosomal subunit protein uS10	polymer	119	13398.8	1	UniProt (P60866) Pfam (PF00338)	Homo sapiens (human)	40S ribosomal protein S20
69	QB (Sa)	Small ribosomal subunit protein eS26	polymer	115	13047.5	1	UniProt (P62854) Pfam (PF01283)	Homo sapiens (human)	40S ribosomal protein S26
70	RB (Sb)	Small ribosomal subunit protein eS27	polymer	84	9480.2	1	UniProt (P42677) Pfam (PF01667)	Homo sapiens (human)	40S ribosomal protein S27,Metallopan-stimulin 1,MPS-1
71	SB (Sc)	Small ribosomal subunit protein eS25	polymer	125	13776.2	1	UniProt (P62851) Pfam (PF03297)	Homo sapiens (human)	40S ribosomal protein S25
72	TB (Sd)	Small ribosomal subunit protein eS28	polymer	69	7855.1	1	UniProt (P62857) Pfam (PF01200)	Homo sapiens (human)	40S ribosomal protein S28
73	UB (Se)	FAU ubiquitin-like and ribosomal protein S30	polymer	133	14415.7	1	UniProt (P62861) Pfam (PF00240) Pfam (PF04758)	Homo sapiens (human)
74	VB (Sf)	Small ribosomal subunit protein uS14	polymer	56	6690.8	1	UniProt (P62273) Pfam (PF00253)	Homo sapiens (human)	40S ribosomal protein S29
75	WB (Sg)	Receptor of activated protein C kinase 1	polymer	317	35115.7	1	UniProt (P63244) Pfam (PF00400)	Homo sapiens (human)	Cell proliferation-inducing gene 21 protein,Guanine nucleotide-binding protein subunit beta-2-like 1,Guanine nucleotide-binding protein subunit beta-like protein 12.3,Human lung cancer oncogene 7 protein,HLC-7,Receptor for activated C kinase,Small ribosomal subunit protein RACK1
76	XB (So)	Small ribosomal subunit protein eS32	polymer	25	3473.5	1	UniProt (P62945) Pfam (PF05162)	Homo sapiens (human)	60S ribosomal protein L41,HG12,Large ribosomal subunit protein eL41
77	YB (Sy)	Small ribosomal subunit protein eS12	polymer	132	14539.0	1	UniProt (P25398) Pfam (PF01248)	Homo sapiens (human)	40S ribosomal protein S12
78	ZB (Sz)	Ubiquitin-40S ribosomal protein S27a	polymer	156	18004.0	1	UniProt (P62979) Pfam (PF00240) Pfam (PF01599)	Homo sapiens (human)	Ubiquitin carboxyl extension protein 80
79	AC (S2)	18S rRNA	polymer	1869	603582.1	1		Homo sapiens (human)
80	AD, AE, AF, AG, AH... (L5, S2, L1, LD, LI...)	MAGNESIUM ION	non-polymer		24.3	321	Chemie (MG) PubChem (888)
81	AL, AM, AN, AR, AS... (L5, L9, Sa, S2, LC...)	POTASSIUM ION	non-polymer		39.1	94	Chemie (K) PubChem (813)
82	IC (L5)	2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL	non-polymer		282.3	1	Chemie (B3P) PubChem (125132)
83	BN, IM, MM, NM, QM... (Sf, LP, Le, Lg, Lo...)	ZINC ION	non-polymer		65.4	8	Chemie (ZN) PubChem (32051)
84	XM (SX)	N-[4-(5-benzamido-1-methyl-1H-pyrazol-3-yl)phenyl]-2-chlorobenzamide	non-polymer		430.9	1	Chemie (A1BNL)
85	AT, AU, AV, BT, BU... (LO, Lp, Sb, LP, Lz...)	water	water		18.0	6717	Chemie (HOH)

Sequence modifications

LF: 1 - 248 (UniProt: P18124)

PDB	External Database	Details
Ser 173	Ala 173	conflict

Ll: 2 - 137 (UniProt: P46779)

PDB	External Database	Details
Ace 2	-	acetylation

Lo: 30 - 128 (UniProt: P62987)

PDB	External Database	Details
-	Gly 35	deletion
-	Ile 36	deletion
-	Pro 37	deletion
-	Pro 38	deletion
-	Asp 39	deletion
-	Gln 40	deletion
-	Gln 41	deletion
-	Arg 42	deletion
-	Leu 43	deletion
-	Ile 44	deletion
-	Phe 45	deletion
-	Ala 46	deletion
-	Gly 47	deletion
-	Lys 48	deletion
-	Gln 49	deletion
-	Leu 50	deletion
-	Glu 51	deletion
-	Asp 52	deletion
-	Gly 53	deletion
-	Arg 54	deletion
-	Thr 55	deletion
-	Leu 56	deletion
-	Ser 57	deletion
-	Asp 58	deletion
-	Tyr 59	deletion
-	Asn 60	deletion
-	Ile 61	deletion
-	Gln 62	deletion
-	Lys 63	deletion

SA: 2 - 295 (UniProt: P08865)

PDB	External Database	Details
Ace 2	-	acetylation

SO: 1 - 151 (UniProt: P62263)

PDB	External Database	Details
Ias 138	Asp 138	conflict

Contents of the asymmetric unit

Polymers	Number of chains	79
	Total formula weight	3786292.8
Non-Polymers*	Number of molecules	425
	Total formula weight	12713.6
All*	Total formula weight	3799006.4

*Water molecules are not included.