9MIX

Cryo-EM structure of human NBCn2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Sodium-driven chloride bicarbonate exchanger	polymer	981	110991.4	2	UniProt (Q6U841)	Homo sapiens (human)	Solute carrier family 4 member 10
2	C, D, E, F, G... (A, B)	CHOLESTEROL	non-polymer		386.7	10	Chemie (CLR) PubChem (5997)
3	H, N (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG) PubChem (24139)

Sequence modifications

A, B: 160 - 1118 (UniProt: Q6U841)

PDB	External Database	Details
Met 159	-	initiating methionine
-	Asn 231	deletion
-	Arg 232	deletion
-	Ile 233	deletion
-	Pro 234	deletion
-	Ile 235	deletion
-	Val 236	deletion
-	Arg 237	deletion
-	Ser 238	deletion
-	Phe 239	deletion
-	Ala 240	deletion
-	Asp 241	deletion
-	Ile 242	deletion
-	Gly 243	deletion
-	Lys 244	deletion
-	Lys 245	deletion
-	Gln 246	deletion
-	Ser 247	deletion
-	Glu 248	deletion
-	Pro 249	deletion
-	Asn 250	deletion
-	Ser 251	deletion
-	Met 252	deletion
-	Asp 253	deletion
-	Lys 254	deletion
-	Asn 255	deletion
-	Ala 256	deletion
-	Gly 257	deletion
-	Gln 258	deletion
-	Val 259	deletion
-	Val 260	deletion
-	Ser 261	deletion
-	Pro 262	deletion
-	Gln 263	deletion
-	Ser 264	deletion
-	Ala 265	deletion
-	Pro 266	deletion
-	Ala 267	deletion
-	Cys 268	deletion
-	Val 269	deletion
-	Glu 270	deletion
-	Asn 271	deletion
-	Lys 272	deletion
-	Asn 273	deletion
-	Asp 274	deletion
-	Val 275	deletion
-	Ser 276	deletion
-	Arg 277	deletion
-	Glu 278	deletion
-	Asn 279	deletion
-	Ser 280	deletion
-	Thr 281	deletion
-	Val 282	deletion
-	Asp 283	deletion
-	Phe 284	deletion
-	Ser 285	deletion
-	Lys 286	deletion
-	Gly 287	deletion
-	Leu 288	deletion
-	Gly 289	deletion
-	Gly 290	deletion
-	Gln 291	deletion
-	Gln 292	deletion
-	Lys 293	deletion
-	Gly 294	deletion
-	His 295	deletion
-	Thr 296	deletion
-	Ser 297	deletion
-	Pro 298	deletion
-	Cys 299	deletion
Gly 1119	-	expression tag
Arg 1120	-	expression tag
Pro 1121	-	expression tag
Leu 1122	-	expression tag
Glu 1123	-	expression tag
Val 1124	-	expression tag
Leu 1125	-	expression tag
Phe 1126	-	expression tag
Gln 1127	-	expression tag
Gly 1128	-	expression tag
Pro 1129	-	expression tag
His 1130	-	expression tag
His 1131	-	expression tag
His 1132	-	expression tag
His 1133	-	expression tag
His 1134	-	expression tag
His 1135	-	expression tag
His 1136	-	expression tag
His 1137	-	expression tag
His 1138	-	expression tag
His 1139	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	221982.7
Non-Polymers*	Number of molecules	12
	Total formula weight	4309.0
All*	Total formula weight	226291.7

*Water molecules are not included.