9MI6
Crystal structure of human FcRn in complex with nipocalimab Fab fragment
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | IgG receptor FcRn large subunit p51 | polymer | 280 | 31237.0 | 1 | UniProt (P55899) Pfam (PF00129) Pfam (PF07654) | Homo sapiens (human) | FcRn,IgG Fc fragment receptor transporter alpha chain,Neonatal Fc receptor |
| 2 | B (B) | Beta-2-microglobulin | polymer | 99 | 11748.2 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | |
| 3 | C (H) | nipocalimab Fab heavy chain | polymer | 220 | 23082.8 | 1 | Homo sapiens | ||
| 4 | D (L) | nipocalimab Fab light chain | polymer | 216 | 22593.9 | 1 | Homo sapiens | ||
| 5 | E (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 6 | F, G, H, I (A, B, H, L) | water | water | 18.0 | 265 | Chemie (HOH) |
Sequence modifications
A: 1 - 274 (UniProt: P55899)
| PDB | External Database | Details |
|---|---|---|
| His 275 | - | expression tag |
| His 276 | - | expression tag |
| His 277 | - | expression tag |
| His 278 | - | expression tag |
| His 279 | - | expression tag |
| His 280 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 88661.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 88883.0 |
