9MHH
PI3KC3-C1 in complex with RAB1A. VPS34 kinase domain active conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphoinositide 3-kinase regulatory subunit 4 | polymer | 1409 | 158808.5 | 1 | UniProt (Q99570) Pfam (PF00069) Pfam (PF22956) Pfam (PF00400) | Homo sapiens (human) | PI3-kinase regulatory subunit 4,PI3-kinase p150 subunit,Phosphoinositide 3-kinase adaptor protein |
| 2 | B (B) | Phosphatidylinositol 3-kinase catalytic subunit type 3 | polymer | 887 | 101680.3 | 1 | UniProt (Q8NEB9) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) | Homo sapiens (human) | PI3-kinase type 3,PI3K type 3,PtdIns-3-kinase type 3,Phosphatidylinositol 3-kinase p100 subunit,Phosphoinositide-3-kinase class 3,hVps34 |
| 3 | C (C) | Beclin 1-associated autophagy-related key regulator | polymer | 492 | 55387.3 | 1 | UniProt (Q6ZNE5) Pfam (PF10186) | Homo sapiens (human) | |
| 4 | D (D) | Beclin-1 | polymer | 450 | 51953.1 | 1 | UniProt (Q14457) Pfam (PF17675) Pfam (PF04111) Pfam (PF15285) | Homo sapiens (human) | Coiled-coil myosin-like BCL2-interacting protein,Protein GT197 |
| 5 | E (E) | Ras-related protein Rab-1A | polymer | 226 | 25206.5 | 1 | UniProt (P62820) Pfam (PF00071) | Homo sapiens (human) | YPT1-related protein |
| 6 | F, I (A, E) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 7 | G, H (A, E) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) |
Sequence modifications
A: 2 - 1358 (UniProt: Q99570)
E: 1 - 205 (UniProt: P62820)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Gly 1359 | - | expression tag |
| Thr 1360 | - | expression tag |
| Glu 1361 | - | expression tag |
| Asn 1362 | - | expression tag |
| Leu 1363 | - | expression tag |
| Tyr 1364 | - | expression tag |
| Phe 1365 | - | expression tag |
| Gln 1366 | - | expression tag |
| Ser 1367 | - | expression tag |
| Gly 1368 | - | expression tag |
| Met 1369 | - | expression tag |
| Ala 1370 | - | expression tag |
| Ala 1371 | - | expression tag |
| Trp 1372 | - | expression tag |
| Ser 1373 | - | expression tag |
| His 1374 | - | expression tag |
| Pro 1375 | - | expression tag |
| Gln 1376 | - | expression tag |
| Phe 1377 | - | expression tag |
| Glu 1378 | - | expression tag |
| Lys 1379 | - | expression tag |
| Gly 1380 | - | expression tag |
| Gly 1381 | - | expression tag |
| Gly 1382 | - | expression tag |
| Ala 1383 | - | expression tag |
| Arg 1384 | - | expression tag |
| Gly 1385 | - | expression tag |
| Gly 1386 | - | expression tag |
| Ser 1387 | - | expression tag |
| Gly 1388 | - | expression tag |
| Gly 1389 | - | expression tag |
| Gly 1390 | - | expression tag |
| Ser 1391 | - | expression tag |
| Trp 1392 | - | expression tag |
| Ser 1393 | - | expression tag |
| His 1394 | - | expression tag |
| Pro 1395 | - | expression tag |
| Gln 1396 | - | expression tag |
| Phe 1397 | - | expression tag |
| Glu 1398 | - | expression tag |
| Lys 1399 | - | expression tag |
| Gly 1400 | - | expression tag |
| Phe 1401 | - | expression tag |
| Asp 1402 | - | expression tag |
| Tyr 1403 | - | expression tag |
| Lys 1404 | - | expression tag |
| Asp 1405 | - | expression tag |
| Asp 1406 | - | expression tag |
| Asp 1407 | - | expression tag |
| Asp 1408 | - | expression tag |
| Lys 1409 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -20 | - | expression tag |
| Lys -19 | - | expression tag |
| Ser -18 | - | expression tag |
| Ser -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| Glu -10 | - | expression tag |
| Asn -9 | - | expression tag |
| Leu -8 | - | expression tag |
| Tyr -7 | - | expression tag |
| Phe -6 | - | expression tag |
| Gln -5 | - | expression tag |
| Ser -4 | - | expression tag |
| Asn -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Met -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Leu 70 | Gln 70 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 393035.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1095.0 | |
| All* | Total formula weight | 394130.7 |
