9MGQ
Crystal structure of PRMT5:MEP50 in complex with sinefungin and compound 47
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein arginine N-methyltransferase 5 | polymer | 645 | 73763.6 | 1 | UniProt (O14744) Pfam (PF17285) Pfam (PF05185) Pfam (PF17286) | Homo sapiens (human) | 72 kDa ICln-binding protein,Histone-arginine N-methyltransferase PRMT5,Jak-binding protein 1,Shk1 kinase-binding protein 1 homolog,SKB1Hs |
| 2 | B (B) | Methylosome protein 50 | polymer | 350 | 37862.4 | 1 | UniProt (Q9BQA1) Pfam (PF00400) | Homo sapiens (human) | MEP-50,Androgen receptor cofactor p44,WD repeat-containing protein 77,p44/Mep50 |
| 3 | C (A) | SINEFUNGIN | non-polymer | 381.4 | 1 | Chemie (SFG) | |||
| 4 | D (A) | 2-(cyclobutylamino)-N-{(2R)-2-hydroxy-2-[(3S)-1,2,3,4-tetrahydroisoquinolin-3-yl]ethyl}pyridine-4-carboxamide | non-polymer | 366.5 | 1 | Chemie (A1BLG) | |||
| 5 | E, F, FA, G, GA... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 19 | Chemie (EDO) | |||
| 6 | AA, BA, HA, V, W... (A, B) | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
| 7 | CA, DA, EA (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 3 | Chemie (PEG) | |||
| 8 | IA, JA (A, B) | water | water | 18.0 | 369 | Chemie (HOH) |
Sequence modifications
A: 2 - 637 (UniProt: O14744)
B: 2 - 342 (UniProt: Q9BQA1)
| PDB | External Database | Details |
|---|---|---|
| Met -7 | - | initiating methionine |
| Asp -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| Lys -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Asp 0 | - | expression tag |
| Lys 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -7 | - | initiating methionine |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| His 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 111626.0 | |
| Non-Polymers* | Number of molecules | 32 |
| Total formula weight | 3014.0 | |
| All* | Total formula weight | 114640.0 |
