9MF0
Crystal structure of KRAS(GDP) bound to LZTR1(Kelch domain)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G, I (A, C, E, G, I) | Isoform 2B of GTPase KRas | polymer | 170 | 19240.7 | 5 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | B, D, F, H, J (B, D, F, H, J) | Leucine-zipper-like transcriptional regulator 1 | polymer | 322 | 36592.1 | 5 | UniProt (Q8N653) Pfam (PF13418) Pfam (PF13415) Pfam (PF01344) | Homo sapiens (human) | LZTR-1 |
| 3 | K, N, P, R, T (A, C, E, G, I) | MAGNESIUM ION | non-polymer | 24.3 | 5 | Chemie (MG) | |||
| 4 | L, M, O, Q, S (A, C, E, G, I) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 5 | Chemie (GDP) | |||
| 5 | AA, BA, CA, U, V... (G, H, I, A, B...) | water | water | 18.0 | 26 | Chemie (HOH) |
Sequence modifications
A, C, E, G, I: 1 - 169 (UniProt: P01116)
B, D, F, H, J: 50 - 329 (UniProt: Q8N653)
B, D, F, H, J: 330 - 422 (UniProt: Q8N653)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ala 35 | Thr 35 | engineered mutation |
| Ala 62 | Glu 62 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 49 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 279164.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2337.5 | |
| All* | Total formula weight | 281501.6 |
