9MC6
Cryo-EM structure of Human UBA1-UBE2O-Ub -Transthiolation state 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Ubiquitin-like modifier-activating enzyme 1 | polymer | 1058 | 117976.6 | 1 | UniProt (P22314) | Homo sapiens (human) | Protein A1S9,Ubiquitin-activating enzyme E1 |
| 2 | B (B) | (E3-independent) E2 ubiquitin-conjugating enzyme | polymer | 1292 | 141554.2 | 1 | UniProt (Q9C0C9) | Homo sapiens (human) | E2/E3 hybrid ubiquitin-protein ligase UBE2O,Ubiquitin carrier protein O,Ubiquitin-conjugating enzyme E2 O,Ubiquitin-conjugating enzyme E2 of 230 kDa,Ubiquitin-conjugating enzyme E2-230K,Ubiquitin-protein ligase O |
| 3 | C (C) | Ubiquitin | polymer | 76 | 8576.8 | 1 | UniProt (P0CG47) | Homo sapiens (human) | |
| 4 | D (A) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 1 | Chemie (AMP) PubChem (6083) PubChem (224) PubChem (162290139) PubChem (638042) PubChem (34768) PubChem (83862) PubChem (446048) PubChem (515384) PubChem (1549371) PubChem (5316444) PubChem (5742864) PubChem (122197642) PubChem (12358354) PubChem (12358355) PubChem (16397049) PubChem (16760266) PubChem (40459109) PubChem (40467049) PubChem (40469468) PubChem (44348067) PubChem (46875232) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (162946266) PubChem (171699505) PubChem (12163610) PubChem (92144436) PubChem (45358029) PubChem (46874558) |
Sequence modifications
B: 1 - 1292 (UniProt: Q9C0C9)
| PDB | External Database | Details |
|---|---|---|
| Phe 50 | Ser 50 | conflict |
| Ser 1207 | Gly 1207 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 268107.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 347.2 | |
| All* | Total formula weight | 268454.8 |
