9MBZ
Cryo-EM structure of human FcRL4 bound to IgA-Fc/J
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (F) | Interleukin-2,Fc receptor-like protein 4 | polymer | 413 | 47055.6 | 1 | UniProt (P60568) UniProt (Q96PJ5) | Homo sapiens (human) | IL-2,T-cell growth factor,TCGF,FcR-like protein 4,FcRL4,Fc receptor homolog 4,FcRH4,IFGP family protein 2,hIFGP2,Immune receptor translocation-associated protein 1 |
| 2 | B, C, D, E (A, B, C, D) | Interleukin-2,Isoform 1 of Immunoglobulin heavy constant alpha 1 | polymer | 291 | 31445.7 | 4 | UniProt (P60568) UniProt (P01876) | Homo sapiens (human) | IL-2,T-cell growth factor,TCGF,Ig alpha-1 chain C region,Ig alpha-1 chain C region BUR,Ig alpha-1 chain C region TRO |
| 3 | F (J) | Immunoglobulin J chain | polymer | 168 | 19204.7 | 1 | UniProt (P01591) | Homo sapiens (human) | Joining chain of multimeric IgA and IgM |
| 4 | G (E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 5 | H, I, J, K, L (F, A, B, C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) PubChem (24139) |
Sequence modifications
F: -4 - 16 (UniProt: P60568)
F: 20 - 387 (UniProt: Q96PJ5)
A, B, C, D: 182 - 202 (UniProt: P60568)
A, B, C, D: 241 - 472 (UniProt: P01876)
J: -22 - 136 (UniProt: P01591)
| PDB | External Database | Details |
|---|---|---|
| Arg 17 | - | linker |
| Ile 18 | - | linker |
| His 19 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| His 388 | - | expression tag |
| His 389 | - | expression tag |
| His 390 | - | expression tag |
| His 391 | - | expression tag |
| His 392 | - | expression tag |
| His 393 | - | expression tag |
| His 394 | - | expression tag |
| His 395 | - | expression tag |
| His 396 | - | expression tag |
| His 397 | - | expression tag |
| Ser 398 | - | expression tag |
| Arg 399 | - | expression tag |
| Val 400 | - | expression tag |
| Asp 401 | - | expression tag |
| Tyr 402 | - | expression tag |
| Lys 403 | - | expression tag |
| Asp 404 | - | expression tag |
| Asp 405 | - | expression tag |
| Asp 406 | - | expression tag |
| Asp 407 | - | expression tag |
| Lys 408 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Arg 203 | - | linker |
| Ile 204 | - | linker |
| His 205 | - | linker |
| Met 206 | - | linker |
| Ser 207 | - | linker |
| Ala 208 | - | linker |
| Trp 209 | - | linker |
| Ser 210 | - | linker |
| His 211 | - | linker |
| Pro 212 | - | linker |
| Gln 213 | - | linker |
| Phe 214 | - | linker |
| Glu 215 | - | linker |
| Lys 216 | - | linker |
| Gly 217 | - | linker |
| Gly 218 | - | linker |
| Gly 219 | - | linker |
| Ser 220 | - | linker |
| Gly 221 | - | linker |
| Gly 222 | - | linker |
| Gly 223 | - | linker |
| Ser 224 | - | linker |
| Gly 225 | - | linker |
| Gly 226 | - | linker |
| Ser 227 | - | linker |
| Ala 228 | - | linker |
| Trp 229 | - | linker |
| Ser 230 | - | linker |
| His 231 | - | linker |
| Pro 232 | - | linker |
| Gln 233 | - | linker |
| Phe 234 | - | linker |
| Glu 235 | - | linker |
| Lys 236 | - | linker |
| Ile 237 | - | linker |
| Asp 238 | - | linker |
| Thr 239 | - | linker |
| Thr 240 | - | linker |
J: -22 - 136 (UniProt: P01591)
| PDB | External Database | Details |
|---|---|---|
| Tyr 137 | - | expression tag |
| Pro 138 | - | expression tag |
| Tyr 139 | - | expression tag |
| Asp 140 | - | expression tag |
| Val 141 | - | expression tag |
| Pro 142 | - | expression tag |
| Asp 143 | - | expression tag |
| Tyr 144 | - | expression tag |
| Ala 145 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 192043.1 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 570.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1106.0 | |
| All* | Total formula weight | 193719.7 |
