9MBQ
Substrate-engaged human 26S proteasome bound to midnolin with RPT5 at top of spiral staircase
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (U) | 26S proteasome non-ATPase regulatory subunit 1 | polymer | 921 | 102404.4 | 1 | UniProt (Q99460) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN2,26S proteasome regulatory subunit S1,26S proteasome subunit p112 |
| 2 | B (V) | 26S proteasome non-ATPase regulatory subunit 3 | polymer | 480 | 54755.7 | 1 | UniProt (O43242) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN3,26S proteasome regulatory subunit S3,Proteasome subunit p58 |
| 3 | C (W) | 26S proteasome non-ATPase regulatory subunit 12 | polymer | 456 | 52979.4 | 1 | UniProt (O00232) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN5,26S proteasome regulatory subunit p55 |
| 4 | D (X) | 26S proteasome non-ATPase regulatory subunit 11 | polymer | 422 | 47526.7 | 1 | UniProt (O00231) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN6,26S proteasome regulatory subunit S9,26S proteasome regulatory subunit p44.5 |
| 5 | E (Y) | 26S proteasome non-ATPase regulatory subunit 6 | polymer | 389 | 45592.3 | 1 | UniProt (Q15008) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN7,26S proteasome regulatory subunit S10,Breast cancer-associated protein SGA-113M,Phosphonoformate immuno-associated protein 4,Proteasome regulatory particle subunit p44S10,p42A |
| 6 | F (Z) | 26S proteasome non-ATPase regulatory subunit 7 | polymer | 324 | 37086.4 | 1 | UniProt (P51665) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN8,26S proteasome regulatory subunit S12,Mov34 protein homolog,Proteasome subunit p40 |
| 7 | G (a) | 26S proteasome non-ATPase regulatory subunit 13 | polymer | 376 | 42995.4 | 1 | UniProt (Q9UNM6) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN9,26S proteasome regulatory subunit S11,26S proteasome regulatory subunit p40.5 |
| 8 | H (b) | 26S proteasome non-ATPase regulatory subunit 4 | polymer | 377 | 40781.6 | 1 | UniProt (P55036) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN10,26S proteasome regulatory subunit S5A,Antisecretory factor 1,AF,ASF,Multiubiquitin chain-binding protein |
| 9 | I (c) | 26S proteasome non-ATPase regulatory subunit 14 | polymer | 310 | 34620.0 | 1 | UniProt (O00487) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN11,26S proteasome-associated PAD1 homolog 1 |
| 10 | J (d) | 26S proteasome non-ATPase regulatory subunit 8 | polymer | 350 | 39667.9 | 1 | UniProt (P48556) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN12,26S proteasome regulatory subunit S14,p31 |
| 11 | K (e) | 26S proteasome complex subunit SEM1 | polymer | 70 | 8284.6 | 1 | UniProt (P60896) | Homo sapiens (human) | 26S proteasome complex subunit DSS1,Deleted in split hand/split foot protein 1,Split hand/foot deleted protein 1,Split hand/foot malformation type 1 protein |
| 12 | L (A) | 26S proteasome regulatory subunit 7 | polymer | 433 | 48700.8 | 1 | UniProt (P35998) | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT1,Proteasome 26S subunit ATPase 2 |
| 13 | M (B) | 26S proteasome regulatory subunit 4 | polymer | 440 | 49260.5 | 1 | UniProt (P62191) | Homo sapiens (human) | P26s4,26S proteasome AAA-ATPase subunit RPT2,Proteasome 26S subunit ATPase 1 |
| 14 | N (C) | 26S proteasome regulatory subunit 8 | polymer | 406 | 45694.0 | 1 | UniProt (P62194) | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT6,Proteasome 26S subunit ATPase 5,Proteasome subunit p45,p45/SUG |
| 15 | O (D) | 26S proteasome regulatory subunit 6B | polymer | 418 | 47426.1 | 1 | UniProt (P43686) | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT3,MB67-interacting protein,MIP224,Proteasome 26S subunit ATPase 4,Tat-binding protein 7,TBP-7 |
| 16 | P (E) | 26S proteasome regulatory subunit 10B | polymer | 389 | 44241.0 | 1 | UniProt (P62335) | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT4,Conserved ATPase domain protein 44,CADp44,Proteasome 26S subunit ATPase 6,Proteasome subunit p42 |
| 17 | Q (F) | 26S proteasome regulatory subunit 6A | polymer | 439 | 49266.5 | 1 | UniProt (P17980) | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT5,Proteasome 26S subunit ATPase 3,Proteasome subunit P50,Tat-binding protein 1,TBP-1 |
| 18 | FA, R (G, g) | Proteasome subunit alpha type-6 | polymer | 245 | 27301.3 | 2 | UniProt (P60900) | Homo sapiens (human) | 27 kDa prosomal protein,PROS-27,p27K,Macropain iota chain,Multicatalytic endopeptidase complex iota chain,Proteasome iota chain,Proteasome subunit alpha-1,alpha-1 |
| 19 | GA, S (H, h) | Proteasome subunit alpha type-2 | polymer | 233 | 25796.3 | 2 | UniProt (P25787) | Homo sapiens (human) | Macropain subunit C3,Multicatalytic endopeptidase complex subunit C3,Proteasome component C3,Proteasome subunit alpha-2,alpha-2 |
| 20 | HA, T (I, i) | Proteasome subunit alpha type-4 | polymer | 260 | 29394.6 | 2 | UniProt (P25789) | Homo sapiens (human) | Macropain subunit C9,Multicatalytic endopeptidase complex subunit C9,Proteasome component C9,Proteasome subunit L,Proteasome subunit alpha-3,alpha-3 |
| 21 | IA, U (J, j) | Proteasome subunit alpha type-7 | polymer | 247 | 27798.7 | 2 | UniProt (O14818) | Homo sapiens (human) | Proteasome subunit RC6-1,Proteasome subunit XAPC7,Proteasome subunit alpha-4,alpha-4 |
| 22 | JA, V (K, k) | Proteasome subunit alpha type-5 | polymer | 240 | 26304.8 | 2 | UniProt (P28066) | Homo sapiens (human) | Macropain zeta chain,Multicatalytic endopeptidase complex zeta chain,Proteasome subunit alpha-5,alpha-5,Proteasome zeta chain |
| 23 | KA, W (L, l) | Isoform Long of Proteasome subunit alpha type-1 | polymer | 268 | 30150.3 | 2 | UniProt (P25786) | Homo sapiens (human) | 30 kDa prosomal protein,PROS-30,Macropain subunit C2,Multicatalytic endopeptidase complex subunit C2,Proteasome component C2,Proteasome nu chain,Proteasome subunit alpha-6,alpha-6 |
| 24 | LA, X (M, m) | Proteasome subunit alpha type-3 | polymer | 254 | 28338.1 | 2 | UniProt (P25788) | Homo sapiens (human) | Macropain subunit C8,Multicatalytic endopeptidase complex subunit C8,Proteasome component C8,Proteasome subunit alpha-7,alpha-7 |
| 25 | MA, Y (N, n) | Proteasome subunit beta type-6 | polymer | 238 | 25246.5 | 2 | UniProt (P28072) | Homo sapiens (human) | Macropain delta chain,Multicatalytic endopeptidase complex delta chain,Proteasome delta chain,Proteasome subunit Y,Proteasome subunit beta-1,beta-1 |
| 26 | NA, Z (O, o) | Proteasome subunit beta type-7 | polymer | 276 | 29869.2 | 2 | UniProt (Q99436) | Homo sapiens (human) | Macropain chain Z,Multicatalytic endopeptidase complex chain Z,Proteasome subunit Z,Proteasome subunit beta-2,beta-2 |
| 27 | AA, OA (P, p) | Proteasome subunit beta type-3 | polymer | 204 | 22841.7 | 2 | UniProt (P49720) | Homo sapiens (human) | Proteasome chain 13,Proteasome component C10-II,Proteasome subunit beta-3,beta-3,Proteasome theta chain |
| 28 | BA, PA (Q, q) | Proteasome subunit beta type-2 | polymer | 201 | 22864.3 | 2 | UniProt (P49721) | Homo sapiens (human) | Macropain subunit C7-I,Multicatalytic endopeptidase complex subunit C7-I,Proteasome component C7-I,Proteasome subunit beta-4,beta-4 |
| 29 | CA, QA (R, r) | Proteasome subunit beta type-5 | polymer | 262 | 28379.1 | 2 | UniProt (P28074) | Homo sapiens (human) | Macropain epsilon chain,Multicatalytic endopeptidase complex epsilon chain,Proteasome chain 6,Proteasome epsilon chain,Proteasome subunit MB1,Proteasome subunit X,Proteasome subunit beta-5,beta-5 |
| 30 | DA, RA (S, s) | Proteasome subunit beta type-1 | polymer | 240 | 26391.2 | 2 | UniProt (P20618) | Homo sapiens (human) | Macropain subunit C5,Multicatalytic endopeptidase complex subunit C5,Proteasome component C5,Proteasome gamma chain,Proteasome subunit beta-6,beta-6 |
| 31 | EA, SA (T, t) | Proteasome subunit beta type-4 | polymer | 263 | 29100.0 | 2 | UniProt (P28070) | Homo sapiens (human) | 26 kDa prosomal protein,HsBPROS26,PROS-26,Macropain beta chain,Multicatalytic endopeptidase complex beta chain,Proteasome beta chain,Proteasome chain 3,HsN3,Proteasome subunit beta-7,beta-7 |
| 32 | TA (f) | Midnolin | polymer | 468 | 49278.7 | 1 | UniProt (Q504T8) | Homo sapiens (human) | Midbrain nucleolar protein |
| 33 | UA (x) | 26S proteasome non-ATPase regulatory subunit 2 | polymer | 908 | 100313.6 | 1 | UniProt (Q13200) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN1,26S proteasome regulatory subunit S2,26S proteasome subunit p97,Protein 55.11,Tumor necrosis factor type 1 receptor-associated protein 2 |
| 34 | VA (v) | substrate peptide | polymer | 14 | 1209.5 | 1 | Homo sapiens | ||
| 35 | WA (c) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 36 | BB, FB, XA, ZA (C, F, A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 4 | Chemie (ATP) | |||
| 37 | AB, CB, GB, YA (B, C, F, A) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) PubChem (888) | |||
| 38 | DB, EB (D, E) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) | |||
| 39 | HB, IB, JB, KB, LB... (N, O, R, n, o...) | N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-4-methyl-1-oxopentan-2-yl]-L-leucinamide | non-polymer | 475.6 | 6 | Chemie (LDZ) PubChem (42636703) PubChem (44119981) PubChem (44367242) PubChem (45103781) PubChem (45103890) PubChem (45104082) PubChem (45104083) PubChem (21118289) PubChem (45103889) PubChem (107707) PubChem (58864900) PubChem (60008819) PubChem (87400659) PubChem (88909681) PubChem (89084460) PubChem (92851396) PubChem (462382) PubChem (6914692) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 48 |
| Total formula weight | 1701636.9 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 5899.5 | |
| All* | Total formula weight | 1707536.4 |
