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Cryo-EM structure of Gi-bound GPCR

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(D, R)
Metabotropic glutamate receptor 8polymer908101858.42UniProt (O00222)
Pfam (PF01094)
Pfam (PF07562)
Pfam (PF00003)
Homo sapiens (human)mGluR8
2C
(A)
Guanine nucleotide-binding protein G(i) subunit alpha-1polymer35440414.01UniProt (P63096)
Pfam (PF00503)
Homo sapiens (human)Adenylate cyclase-inhibiting G alpha protein
3D
(B)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer34337574.01UniProt (P62873)
Pfam (PF00400)
Homo sapiens (human)Transducin beta chain 1
4E
(C)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)
Homo sapiens (human)G gamma-I
5F, H
(D, R)
4-[(S)-amino(carboxy)methyl]benzene-1,2-dicarboxylic acidnon-polymer239.22Chemie (HVG)
6G
(R)
~{N}-[3-chloranyl-4-(5-chloranylpyridin-2-yl)oxy-phenyl]pyridine-2-carboxamidenon-polymer360.21Chemie (A1ENS)
Sequence modifications
A: 1 - 354 (UniProt: P63096)
PDBExternal DatabaseDetails
Asn 47Ser 47conflict
Ala 203Gly 203conflict
Ala 245Glu 245conflict
Ser 326Ala 326conflict
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
Gly -2-expression tag
Ser -1-expression tag
Ser 0-expression tag
Gly 1-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight289566.0
Non-Polymers*Number of molecules3
Total formula weight838.6
All*Total formula weight290404.6
*Water molecules are not included.

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PDB entries from 2026-01-14

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