9MAN

Structure of Norrin in complex with human Tspan12 large extracellular loop (Tspan12 LEL)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Maltose/maltodextrin-binding periplasmic protein,Norrin	polymer	500	55603.1	2	UniProt (P0AEY0) UniProt (Q00604)	Escherichia coli O157:H7	MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,Norrie disease protein,X-linked exudative vitreoretinopathy 2 protein
2	C, D (D, C)	Maltose/maltodextrin-binding periplasmic protein,Tetraspanin-12	polymer	501	56395.7	2	UniProt (P0AEY0) UniProt (O95859)	Escherichia coli O157:H7	MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,Tspan-12,Tetraspan NET-2,Transmembrane 4 superfamily member 12

Sequence modifications

A, B: -355 - 11 (UniProt: P0AEY0)

PDB	External Database	Details
Gly -366	-	linker
Ser -365	-	linker
His -364	-	expression tag
His -363	-	expression tag
His -362	-	expression tag
His -361	-	expression tag
His -360	-	expression tag
His -359	-	expression tag
His -358	-	expression tag
His -357	-	expression tag
Met -356	-	linker
Asn 12	-	linker
Ala 13	-	linker
Ala 14	-	linker
Ala 15	-	linker
Glu 16	-	linker
Asn 17	-	linker
Leu 18	-	linker
Tyr 19	-	linker
Phe 20	-	linker
Gln 21	-	linker
Gly 22	-	linker
Glu 23	-	linker
Phe 24	-	linker

A, B: 25 - 133 (UniProt: Q00604)
D, C: -265 - 101 (UniProt: P0AEY0)

PDB	External Database	Details
Gly -276	-	linker
Ser -275	-	linker
His -274	-	expression tag
His -273	-	expression tag
His -272	-	expression tag
His -271	-	expression tag
His -270	-	expression tag
His -269	-	expression tag
His -268	-	expression tag
His -267	-	expression tag
Met -266	-	linker
Asn 102	-	linker
Ala 103	-	linker
Ala 104	-	linker
Ala 105	-	linker
Glu 106	-	linker
Asn 107	-	linker
Leu 108	-	linker
Tyr 109	-	linker
Phe 110	-	linker
Gln 111	-	linker
Gly 112	-	linker
Glu 113	-	linker
Phe 114	-	linker

D, C: 115 - 224 (UniProt: O95859)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	223997.6
All*	Total formula weight	223997.6

*Water molecules are not included.