9M9V

Cryo-EM structure of human OAT1 in complex with adefovir

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Isoform 2 of Solute carrier family 22 member 6	polymer	544	59876.5	1	UniProt (Q4U2R8) Pfam (PF00083)	Homo sapiens (human)	Organic anion transporter 1,hOAT1,PAH transporter,hPAHT,Renal organic anion transporter 1,hROAT1
2	B (A)	{[2-(6-AMINO-9H-PURIN-9-YL)ETHOXY]METHYL}PHOSPHONIC ACID	non-polymer		273.2	1	Chemie (5HG)

Sequence modifications

A: 1 - 522 (UniProt: Q4U2R8)

PDB	External Database	Details
His 523	-	expression tag
His 524	-	expression tag
His 525	-	expression tag
His 526	-	expression tag
His 527	-	expression tag
His 528	-	expression tag
His 529	-	expression tag
His 530	-	expression tag
His 531	-	expression tag
His 532	-	expression tag
Gly 533	-	expression tag
Ser 534	-	expression tag
Val 535	-	expression tag
Glu 536	-	expression tag
Asp 537	-	expression tag
Tyr 538	-	expression tag
Lys 539	-	expression tag
Asp 540	-	expression tag
Asp 541	-	expression tag
Asp 542	-	expression tag
Asp 543	-	expression tag
Lys 544	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	59876.5
Non-Polymers*	Number of molecules	1
	Total formula weight	273.2
All*	Total formula weight	60149.7

*Water molecules are not included.