9M41

The crystal structure of full-length PAK2 containing K278R and D368N mutants

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Serine/threonine-protein kinase PAK 2	polymer	547	60605.2	2	UniProt (Q13177) Pfam (PF00786) Pfam (PF00069)	Homo sapiens (human)	Gamma-PAK,PAK65,S6/H4 kinase,p21-activated kinase 2,PAK-2,p58
2	C (B)	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
3	D (B)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

A, B: 1 - 524 (UniProt: Q13177)

PDB	External Database	Details
Met -22	-	initiating methionine
Gly -21	-	expression tag
Ser -20	-	expression tag
Ser -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
Ser -12	-	expression tag
Ser -11	-	expression tag
Gly -10	-	expression tag
Leu -9	-	expression tag
Val -8	-	expression tag
Pro -7	-	expression tag
Arg -6	-	expression tag
Gly -5	-	expression tag
Ser -4	-	expression tag
His -3	-	expression tag
Met -2	-	expression tag
Ala -1	-	expression tag
Ser 0	-	expression tag
Arg 278	Lys 278	engineered mutation
Asn 368	Asp 368	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	121210.4
Non-Polymers*	Number of molecules	1
	Total formula weight	95.0
All*	Total formula weight	121305.4

*Water molecules are not included.