9M0J
Cryo-EM structure of Bombesin receptor type-3 bound to oridonin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(q) subunit alpha-1 | polymer | 361 | 41724.4 | 1 | Homo sapiens | ||
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 344 | 37784.3 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (N) | Nanobody-35 | polymer | 128 | 13885.4 | 1 | synthetic construct | ||
| 5 | E (R) | Bombesin receptor subtype-3 | polymer | 399 | 44452.7 | 1 | UniProt (P32247) Pfam (PF00001) | Homo sapiens (human) | BRS-3 |
| 6 | F (R) | (1beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14R,16beta)-1,6,7,14-tetrahydroxy-7,20-epoxykauran-15-one | non-polymer | 366.4 | 1 | Chemie (ODN) PubChem (137349831) |
Sequence modifications
B: 7 - 345 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Gly 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Leu 4 | - | expression tag |
| Leu 5 | - | expression tag |
| Gln 6 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 145707.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 366.4 | |
| All* | Total formula weight | 146074.4 |
