9LZ2

Cryo-EM structure of PTH1R(V2RC)-beta-arrestin1 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (P)	Long-acting PTH	polymer	36	4274.0	1		synthetic construct
2	B (A)	Beta-arrestin-1	polymer	393	44281.5	1	UniProt (P17870)	Bos taurus (domestic cattle)	Arrestin beta-1,Arrestin-2
3	C (H)	Fab30 heavy chain	polymer	160	17147.0	1		Mus musculus
4	D (L)	Fab30 light chain	polymer	215	23435.1	1		Mus musculus
5	E (R)	Parathyroid hormone/parathyroid hormone-related peptide receptor,Vasopressin V2 receptor	polymer	500	56992.6	1	UniProt (Q03431) UniProt (P30518)	Homo sapiens (human)	PTH/PTHrP type I receptor,PTH/PTHr receptor,Parathyroid hormone 1 receptor,PTH1 receptor,V2R,AVPR V2,Antidiuretic hormone receptor,Renal-type arginine vasopressin receptor

Sequence modifications

A: 1 - 393 (UniProt: P17870)

PDB	External Database	Details
Glu 169	Arg 169	conflict

R: 27 - 1332 (UniProt: Q03431)

PDB	External Database	Details
Ala 188	Gly 188	conflict
Gly 1333	-	linker
Gly 1334	-	linker
Gly 1335	-	linker
Ser 1336	-	linker
Gly 1337	-	linker
Gly 1338	-	linker
Gly 1339	-	linker
Ser 1340	-	linker
Gly 1341	-	linker
Gly 1342	-	linker

R: 1343 - 1368 (UniProt: P30518)

PDB	External Database	Details
Glu 1347	Thr 347	conflict
Glu 1350	Ser 350	conflict

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	146130.3
All*	Total formula weight	146130.3

*Water molecules are not included.