9LYB
Cryo-EM structure of GPR3-G protein-monomer complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 373 | 43621.3 | 1 | UniProt (P63092) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-stimulating G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 339 | 37285.7 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 58 | 6375.3 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (N) | Nanobody 35 | polymer | 128 | 13885.4 | 1 | Homo sapiens | ||
| 5 | E (R) | G-protein coupled receptor 3 | polymer | 279 | 30031.9 | 1 | UniProt (P46089) Pfam (PF00001) | Homo sapiens (human) | ACCA orphan receptor |
Sequence modifications
A: 8 - 394 (UniProt: P63092)
| PDB | External Database | Details |
|---|---|---|
| Asn 54 | Ser 54 | conflict |
| Ala 226 | Gly 212 | conflict |
| Ala 268 | Glu 254 | conflict |
| Lys 271 | Asn 257 | conflict |
| Asp 274 | Lys 260 | conflict |
| Lys 280 | Arg 266 | conflict |
| Asp 284 | Thr 270 | conflict |
| Thr 285 | Ile 271 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 131199.7 | |
| All* | Total formula weight | 131199.7 |
