9LY2
A Cryo-EM structure of LA-PTH-PTH1R-V2RT-Beta-arrestin1 complex (state 1 conformation)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Beta-arrestin-1 | polymer | 391 | 43995.2 | 1 | UniProt (P49407) Pfam (PF00339) Pfam (PF02752) | Homo sapiens (human) | Arrestin beta-1,Non-visual arrestin-2 |
| 2 | B (C) | Fab30H | polymer | 237 | 25551.5 | 1 | Homo sapiens | ||
| 3 | C (E) | Fab30L | polymer | 213 | 23244.8 | 1 | Homo sapiens | ||
| 4 | D (L) | LA-PTH | polymer | 36 | 4274.0 | 1 | Homo sapiens | ||
| 5 | E (R) | Parathyroid hormone/parathyroid hormone-related peptide receptor,Vasopressin V2 receptor | polymer | 507 | 57901.8 | 1 | UniProt (Q03431) UniProt (P30518) Pfam (PF02793) Pfam (PF00002) | Homo sapiens (human) | PTH/PTHrP type I receptor,PTH/PTHr receptor,Parathyroid hormone 1 receptor,PTH1 receptor,V2R,AVPR V2,Antidiuretic hormone receptor,Renal-type arginine vasopressin receptor |
Sequence modifications
B: 4 - 393 (UniProt: P49407)
R: 27 - 502 (UniProt: Q03431)
R: 503 - 531 (UniProt: P30518)
| PDB | External Database | Details |
|---|---|---|
| Met 3 | - | initiating methionine |
| Cys 14 | Pro 14 | conflict |
| Cys 81 | Val 81 | conflict |
| Cys 279 | Ala 279 | conflict |
| Ala 386 | Ile 386 | conflict |
| Ala 387 | Val 387 | conflict |
| Ala 388 | Phe 388 | conflict |
R: 503 - 531 (UniProt: P30518)
| PDB | External Database | Details |
|---|---|---|
| Gly 532 | - | expression tag |
| Ser 533 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 154967.4 | |
| All* | Total formula weight | 154967.4 |
