9LXR
A Cryo-EM structure of LA-PTH-PTH1R-Beta-arrestin1 complex (state 1 conformation)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Beta-arrestin-1 | polymer | 374 | 42131.4 | 1 | UniProt (P49407) Pfam (PF00339) Pfam (PF02752) | Homo sapiens (human) | Arrestin beta-1,Non-visual arrestin-2 |
| 2 | B (C) | Fab30H | polymer | 230 | 24584.5 | 1 | Homo sapiens | ||
| 3 | C (E) | Fab30L | polymer | 215 | 23435.1 | 1 | Homo sapiens | ||
| 4 | D (L) | LA-PTH | polymer | 36 | 4274.0 | 1 | Pfam (PF01279) UniProt (by SIFTS) (F5GZD9) | Homo sapiens | |
| 5 | E (R) | Parathyroid hormone/parathyroid hormone-related peptide receptor | polymer | 482 | 55344.2 | 1 | UniProt (Q03431) Pfam (PF02793) Pfam (PF00002) | Homo sapiens (human) | PTH/PTHrP type I receptor,PTH/PTHr receptor,Parathyroid hormone 1 receptor,PTH1 receptor |
Sequence modifications
B: 4 - 376 (UniProt: P49407)
R: 27 - 507 (UniProt: Q03431)
| PDB | External Database | Details |
|---|---|---|
| Met 3 | - | initiating methionine |
| Cys 14 | Pro 14 | conflict |
| Cys 81 | Val 81 | conflict |
| Cys 279 | Ala 279 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 508 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 149769.1 | |
| All* | Total formula weight | 149769.1 |
