9LX0

DOCK5/ELMO1 complex with RhoG and Rac1 on lipid membrane

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E (A, E)	Engulfment and cell motility protein 1	polymer	733	84379.8	2	UniProt (Q92556) Pfam (PF11841) Pfam (PF04727) Pfam (PF16457)	Homo sapiens (human)	Protein ced-12 homolog
2	B, F (B, F)	Dedicator of cytokinesis protein 5	polymer	1876	216022.4	2	UniProt (Q9H7D0) Pfam (PF20421) Pfam (PF00018) Pfam (PF16172) Pfam (PF14429) Pfam (PF23554) Pfam (PF06920) Pfam (PF20422)	Homo sapiens (human)
3	C, G (C, G)	Rho-related GTP-binding protein RhoG	polymer	214	23692.9	2	UniProt (P84095) Pfam (PF00071)	Homo sapiens (human)
4	D, H (D, H)	Ras-related C3 botulinum toxin substrate 1	polymer	206	23037.5	2	UniProt (P63000) Pfam (PF00071)	Homo sapiens (human)	Cell migration-inducing gene 5 protein,Ras-like protein TC25,p21-Rac1

Sequence modifications

A, E: 1 - 727 (UniProt: Q92556)

PDB	External Database	Details
Gly -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag
Val -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

B, F: 1 - 1870 (UniProt: Q9H7D0)

PDB	External Database	Details
Gly -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Arg 1285	Lys 1285	variant

C, G: 1 - 191 (UniProt: P84095)

PDB	External Database	Details
Gly -6	-	expression tag
Ser -5	-	expression tag
Ser -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Ser -1	-	expression tag
Gly 0	-	expression tag
Leu 61	Gln 61	engineered mutation
Ser 192	-	expression tag
Gly 193	-	expression tag
Pro 194	-	expression tag
Ser 195	-	expression tag
Ser 196	-	expression tag
Gly 197	-	expression tag
His 198	-	expression tag
His 199	-	expression tag
His 200	-	expression tag
His 201	-	expression tag
His 202	-	expression tag
His 203	-	expression tag
His 204	-	expression tag
His 205	-	expression tag
His 206	-	expression tag
His 207	-	expression tag

D, H: 1 - 188 (UniProt: P63000)

PDB	External Database	Details
Gly -6	-	expression tag
Ser -5	-	expression tag
Ser -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Ser -1	-	expression tag
Gly 0	-	expression tag
Ala 15	Gly 15	engineered mutation
Ser 189	-	expression tag
His 190	-	expression tag
His 191	-	expression tag
His 192	-	expression tag
His 193	-	expression tag
His 194	-	expression tag
His 195	-	expression tag
His 196	-	expression tag
His 197	-	expression tag
His 198	-	expression tag
His 199	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	694265.3
All*	Total formula weight	694265.3

*Water molecules are not included.