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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9LWP

Cryo-EM structure of the unliganded human BRS3-Gq complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(R)		Bombesin receptor subtype-3,Oplophorus-luciferin 2-monooxygenase catalytic subunitpolymer61267457.61UniProt (P32247)
UniProt (Q9GV45)
Pfam (PF00001)		Homo sapiens (human)BRS-3,19kOLase
2B
(A)		Guanine nucleotide-binding protein G(i) subunit alpha-2,Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortpolymer24628084.81UniProt (P04899)
UniProt (P63092)
Pfam (PF00503)		Homo sapiens (human)Adenylate cyclase-inhibiting G alpha protein,Adenylate cyclase-stimulating G alpha protein
3C
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer34537915.51UniProt (P54311)
Pfam (PF00400)		Rattus norvegicus (Norway rat)Transducin beta chain 1
4D
(G)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer707729.91UniProt (P63212)
Pfam (PF00631)		Bos taurus (domestic cattle)G gamma-I
Sequence modifications
R: 1 - 399 (UniProt: P32247)
PDBExternal DatabaseDetails
Met -15-initiating methionine
Lys -14-expression tag
Thr -13-expression tag
Ile -12-expression tag
Ile -11-expression tag
Ala -10-expression tag
Leu -9-expression tag
Ser -8-expression tag
Tyr -7-expression tag
Ile -6-expression tag
Phe -5-expression tag
Cys -4-expression tag
Leu -3-expression tag
Val -2-expression tag
Phe -1-expression tag
Ala 0-expression tag
Gly 400-linker
Ser 401-linker
Ser 402-linker
Gly 403-linker
Gly 404-linker
Gly 405-linker
Gly 406-linker
Ser 407-linker
Gly 408-linker
Gly 409-linker
Gly 410-linker
Gly 411-linker
Ser 412-linker
Ser 413-linker
Gly 414-linker
Val 415-linker
R: 416 - 571 (UniProt: Q9GV45)
PDBExternal DatabaseDetails
Glu 419Ala 31conflict
Glu 426Gln 38conflict
Ala 430Gly 42conflict
Leu 433Gln 45conflict
Val 442Leu 54conflict
Leu 446Phe 58conflict
Asn 448Ala 60conflict
Ala 450Gly 62conflict
Arg 458Lys 70conflict
Ile 459Val 71conflict
Arg 461Leu 73conflict
Ala 466Gly 78conflict
Ile 469Ala 81conflict
Ala 482Gly 94conflict
Asp 483Phe 95conflict
Ala 486Gly 98conflict
Gln 487Leu 99conflict
Glu 490Met 102conflict
Val 491Ile 103conflict
Val 505Ile 117conflict
Pro 508His 120conflict
Leu 522Ile 134conflict
Asn 523Asp 135conflict
Glu 530Pro 142conflict
Lys 539Gln 151conflict
Ile 553Tyr 165conflict
Thr 559Asn 171conflict
Met 564Leu 176conflict
Ser 572-expression tag
Gly 573-expression tag
Gly 574-expression tag
Ser 575-expression tag
Glu 576-expression tag
Asn 577-expression tag
Leu 578-expression tag
Tyr 579-expression tag
Phe 580-expression tag
Gln 581-expression tag
Gly 582-expression tag
Gly 583-expression tag
Ser 584-expression tag
Ala 585-expression tag
Gly 586-expression tag
Ser 587-expression tag
Ala 588-expression tag
His 589-expression tag
His 590-expression tag
His 591-expression tag
His 592-expression tag
His 593-expression tag
His 594-expression tag
His 595-expression tag
His 596-expression tag
A: 1 - 39 (UniProt: P04899)
PDBExternal DatabaseDetails
Ser 3Cys 3conflict
Arg 31Ala 31conflict
Thr 33Glu 33conflict
Leu 34Val 34conflict
Arg 35Lys 35conflict
A: 40 - 57 (UniProt: P63092)
PDBExternal DatabaseDetails
Asp 42Gly 49conflict
Asn 43Glu 50conflict
A: 66 - 115 (UniProt: P63092)
PDBExternal DatabaseDetails
Gly 58-linker
Gly 59-linker
Ser 60-linker
Gly 61-linker
Gly 62-linker
Ser 63-linker
Gly 64-linker
Gly 65-linker
Asp 111Ala 249conflict
Asp 114Ser 252conflict
A: 116 - 246 (UniProt: P63092)
PDBExternal DatabaseDetails
Asp 124Leu 272conflict
Lys 195Asp 343conflict
Val 198Leu 346conflict
Asp 199Arg 347conflict
Ile 210Tyr 358conflict
Ala 224Ile 372conflict
Ile 227Val 375conflict
Lys 232Arg 380conflict
Leu 236Gln 384conflict
Gln 237Arg 385conflict
Asn 239His 387conflict
Glu 242Gln 390conflict
Asn 244Glu 392conflict
Val 246Leu 394conflict
B: 2 - 340 (UniProt: P54311)
PDBExternal DatabaseDetails
Met -4-initiating methionine
Gly -3-expression tag
Ser -2-expression tag
Leu -1-expression tag
Leu 0-expression tag
Gln 1-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight141187.8
All*Total formula weight141187.8
*Water molecules are not included.

239149

PDB entries from 2025-07-23

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