9LVK
Cryo-EM structure of CASTOR1 bound human GATOR2 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, H, Q, R (A, K, L, B) | GATOR2 complex protein MIOS | polymer | 875 | 98700.4 | 4 | UniProt (Q9NXC5) Pfam (PF21720) Pfam (PF21719) Pfam (PF17034) | Homo sapiens (human) | |
| 2 | B, I (C, M) | GATOR2 complex protein WDR24 | polymer | 790 | 88327.0 | 2 | UniProt (Q96S15) Pfam (PF00400) | Homo sapiens (human) | |
| 3 | C, J (D, N) | GATOR2 complex protein WDR59 | polymer | 974 | 109938.4 | 2 | UniProt (Q6PJI9) Pfam (PF00400) Pfam (PF17120) | Homo sapiens (human) | WD repeat-containing protein 59 |
| 4 | D, E, F, K, L... (E, F, G, O, P...) | Isoform B of Nucleoporin SEH1 | polymer | 421 | 46636.3 | 6 | UniProt (Q96EE3) Pfam (PF00400) | Homo sapiens (human) | GATOR2 complex protein SEH1,Nup107-160 subcomplex subunit SEH1,SEC13-like protein |
| 5 | G, N (H, R) | Isoform 3 of Protein SEC13 homolog | polymer | 368 | 40791.7 | 2 | UniProt (P55735) Pfam (PF00400) | Homo sapiens (human) | GATOR2 complex protein SEC13,SEC13-like protein 1,SEC13-related protein |
| 6 | O, P (U, V) | Cytosolic arginine sensor for mTORC1 subunit 1 | polymer | 329 | 36265.2 | 2 | UniProt (Q8WTX7) Pfam (PF18700) Pfam (PF13840) Pfam (PF21389) | Homo sapiens (human) | Cellular arginine sensor for mTORC1 protein 1,GATS-like protein 3 |
| 7 | AA, BA, CA, DA, EA... (D, K, M, N, L...) | ZINC ION | non-polymer | 65.4 | 31 | Chemie (ZN) |
Sequence modifications
U, V: 1 - 329 (UniProt: Q8WTX7)
| PDB | External Database | Details |
|---|---|---|
| Ala 304 | Asp 304 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 18 |
| Total formula weight | 1225263.8 | |
| Non-Polymers* | Number of molecules | 31 |
| Total formula weight | 2027.7 | |
| All* | Total formula weight | 1227291.5 |
