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9LQ3

Crystal structure of Linafexor-FXR complex

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Bile acid receptorpolymer22826494.51UniProt (Q96RI1)
Pfam (PF00104)
Homo sapiens (human)Farnesoid X-activated receptor,Farnesol receptor HRR-1,Nuclear receptor subfamily 1 group H member 4,Retinoid X receptor-interacting protein 14,RXR-interacting protein 14
2B
(C)
Nuclear receptor coactivator 2polymer111363.61UniProt (Q15596)Homo sapiens (human)NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2
3C
(A)
Linafexornon-polymer571.41Chemie (A1ELK)
4D, E
(A, C)
waterwater18.014Chemie (HOH)
Sequence modifications
A: 244 - 471 (UniProt: Q96RI1)
PDBExternal DatabaseDetails
Ala 250Gln 264conflict
Ala 277Glu 291conflict
Ala 350Glu 364conflict
Ala 425Glu 439conflict
Lys 432Cys 446conflict
Gln 466Cys 480conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight27858.1
Non-Polymers*Number of molecules1
Total formula weight571.4
All*Total formula weight28429.6
*Water molecules are not included.

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PDB entries from 2026-01-28

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