9LLG
Cryo-EM structure of D1R in complex with de novo designed negative allosteric GEM targeting TM5/6/7
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | D(1A) dopamine receptor,Soluble cytochrome b562 | polymer | 516 | 57093.8 | 1 | UniProt (P21728) UniProt (P0ABE7) | Homo sapiens (human) | Dopamine D1 receptor,Cytochrome b-562 |
| 2 | B (M) | De novo designed negative allosteric GPCR exoframe modulator targeting TM5/6/7 | polymer | 95 | 10962.6 | 1 | Homo sapiens (human) | ||
| 3 | C, E (R) | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) | |||
| 4 | D (R) | Flupentixol | non-polymer | 434.5 | 1 | Chemie (A1EKL) | |||
| 5 | F (M) | PALMITIC ACID | non-polymer | 256.4 | 1 | Chemie (PLM) |
Sequence modifications
R: 2 - 220 (UniProt: P21728)
R: 1233 - 1323 (UniProt: P0ABE7)
R: 276 - 446 (UniProt: P21728)
R: 1233 - 1323 (UniProt: P0ABE7)
| PDB | External Database | Details |
|---|---|---|
| Asp 1324 | - | linker |
| Ala 1325 | - | linker |
| Ile 1326 | - | linker |
| Leu 1327 | - | linker |
| Lys 1328 | - | linker |
| Pro 1329 | - | linker |
| Phe 1330 | - | linker |
| Ile 1331 | - | linker |
| Glu 1332 | - | linker |
| Glu 1333 | - | linker |
| Leu 1334 | - | linker |
| Lys 1335 | - | linker |
| Glu 1336 | - | linker |
| Leu 1337 | - | linker |
| Lys 1338 | - | linker |
| Gly 1339 | - | linker |
| Lys 1340 | - | linker |
| Pro 1341 | - | linker |
| Phe 1342 | - | linker |
| Leu 1343 | - | linker |
| Ile 1344 | - | linker |
| Asp 1345 | - | linker |
| Ala 1346 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Leu 1221 | - | linker |
| Lys 1222 | - | linker |
| Lys 1223 | - | linker |
| Glu 1224 | - | linker |
| Leu 1225 | - | linker |
| Asp 1226 | - | linker |
| Ala 1227 | - | linker |
| Leu 1228 | - | linker |
| Asn 1229 | - | linker |
| Asp 1230 | - | linker |
| Asn 1231 | - | linker |
| Trp 1232 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68056.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1464.3 | |
| All* | Total formula weight | 69520.7 |
