9LLG
Cryo-EM structure of D1R in complex with de novo designed negative allosteric GEM targeting TM5/6/7
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | D(1A) dopamine receptor,Soluble cytochrome b562 | polymer | 516 | 57093.8 | 1 | UniProt (P21728) UniProt (P0ABE7) Pfam (PF00001) | Homo sapiens (human) | Dopamine D1 receptor,Cytochrome b-562 |
| 2 | B (M) | De novo designed negative allosteric GPCR exoframe modulator targeting TM5/6/7 | polymer | 95 | 10962.6 | 1 | Homo sapiens (human) | ||
| 3 | C, E (R) | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) PubChem (16219173) PubChem (16758052) PubChem (304) PubChem (176980071) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (18640088) PubChem (1715243) PubChem (1715244) PubChem (45044259) PubChem (23423981) PubChem (49853509) PubChem (50990013) PubChem (52934537) PubChem (56621683) PubChem (191463) PubChem (57915018) PubChem (57939063) PubChem (58428240) PubChem (58445498) PubChem (58663286) PubChem (368063) PubChem (369319) PubChem (44654663) PubChem (59450329) PubChem (59628412) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (46937002) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (638019) PubChem (59274407) PubChem (1549081) PubChem (1553803) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (89951918) PubChem (90224410) PubChem (5997) PubChem (5283629) PubChem (5284644) PubChem (1551269) PubChem (90070115) PubChem (91298236) PubChem (5315842) PubChem (117965027) PubChem (6432564) PubChem (6710666) PubChem (124146240) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (6419195) PubChem (10861996) PubChem (132837164) PubChem (101624109) PubChem (6994560) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (124225449) PubChem (138967089) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (139566851) PubChem (124429284) PubChem (11463329) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (12120344) PubChem (12156156) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (15939944) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (171828367) PubChem (173516975) PubChem (130459183) PubChem (131992107) PubChem (139568882) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573) | |||
| 4 | D (R) | Flupentixol | non-polymer | 434.5 | 1 | Chemie (A1EKL) | |||
| 5 | F (M) | PALMITIC ACID | non-polymer | 256.4 | 1 | Chemie (PLM) |
Sequence modifications
R: 2 - 220 (UniProt: P21728)
R: 1233 - 1323 (UniProt: P0ABE7)
R: 276 - 446 (UniProt: P21728)
R: 1233 - 1323 (UniProt: P0ABE7)
| PDB | External Database | Details |
|---|---|---|
| Asp 1324 | - | linker |
| Ala 1325 | - | linker |
| Ile 1326 | - | linker |
| Leu 1327 | - | linker |
| Lys 1328 | - | linker |
| Pro 1329 | - | linker |
| Phe 1330 | - | linker |
| Ile 1331 | - | linker |
| Glu 1332 | - | linker |
| Glu 1333 | - | linker |
| Leu 1334 | - | linker |
| Lys 1335 | - | linker |
| Glu 1336 | - | linker |
| Leu 1337 | - | linker |
| Lys 1338 | - | linker |
| Gly 1339 | - | linker |
| Lys 1340 | - | linker |
| Pro 1341 | - | linker |
| Phe 1342 | - | linker |
| Leu 1343 | - | linker |
| Ile 1344 | - | linker |
| Asp 1345 | - | linker |
| Ala 1346 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Leu 1221 | - | linker |
| Lys 1222 | - | linker |
| Lys 1223 | - | linker |
| Glu 1224 | - | linker |
| Leu 1225 | - | linker |
| Asp 1226 | - | linker |
| Ala 1227 | - | linker |
| Leu 1228 | - | linker |
| Asn 1229 | - | linker |
| Asp 1230 | - | linker |
| Asn 1231 | - | linker |
| Trp 1232 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68056.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1464.3 | |
| All* | Total formula weight | 69520.7 |
