9LLA
Ariadne-bound Serotonin 2A (5-HT2A) receptor-Gq complex
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 2 | B (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 3 | C (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(q) subunit alpha | polymer | 361 | 41664.3 | 1 | UniProt (P63096) UniProt (P63092) UniProt (P50148) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein,Adenylate cyclase-stimulating G alpha protein,Guanine nucleotide-binding protein alpha-q |
| 4 | D (R) | 5-hydroxytryptamine receptor 2A | polymer | 471 | 52648.9 | 1 | UniProt (P28223) Pfam (PF00001) | Homo sapiens (human) | 5-HT-2,5-HT-2A,Serotonin receptor 2A |
| 5 | E (R) | (2~{R})-1-(2,5-dimethoxy-4-methyl-phenyl)butan-2-amine | non-polymer | 223.3 | 1 | Chemie (A1EK8) |
Sequence modifications
A: 1 - 19 (UniProt: P63096)
A: 20 - 60 (UniProt: P63092)
A: 61 - 180 (UniProt: P63096)
A: 181 - 228 (UniProt: P63092)
A: 231 - 346 (UniProt: P63092)
A: 347 - 361 (UniProt: P50148)
A: 20 - 60 (UniProt: P63092)
| PDB | External Database | Details |
|---|---|---|
| Arg 32 | Ala 39 | conflict |
| Leu 34 | His 41 | conflict |
| Asp 42 | Gly 49 | conflict |
| Asn 43 | Glu 50 | conflict |
| Tyr 56 | Leu 63 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ser 108 | Phe 108 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 203 | Gly 226 | conflict |
| Asp 226 | Ala 249 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asp 229 | - | linker |
| Tyr 230 | - | linker |
| Asp 239 | Leu 272 | conflict |
| Lys 310 | Asp 343 | conflict |
| Val 313 | Leu 346 | conflict |
| Asp 314 | Arg 347 | conflict |
| Ile 325 | Tyr 358 | conflict |
| Ser 333 | Ala 366 | conflict |
| Ala 339 | Ile 372 | conflict |
| Ile 342 | Val 375 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ile 349 | Thr 347 | conflict |
| Met 353 | Leu 351 | conflict |
| Arg 356 | Lys 354 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 139591.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 223.3 | |
| All* | Total formula weight | 139814.6 |
