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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9LL9

DOI-bound Serotonin 2A (5-HT2A) receptor-Gq complex

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer34037416.91UniProt (P62873)
Pfam (PF25391)		Homo sapiens (human)Transducin beta chain 1
2B
(C)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
3C
(A)		Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(q) subunit alphapolymer36141664.31UniProt (P63096)
UniProt (P63092)
UniProt (P50148)
Pfam (PF00503)		Homo sapiens (human)Adenylate cyclase-inhibiting G alpha protein,Adenylate cyclase-stimulating G alpha protein,Guanine nucleotide-binding protein alpha-q
4D
(R)		5-hydroxytryptamine receptor 2Apolymer47152648.91UniProt (P28223)
Pfam (PF00001)		Homo sapiens (human)5-HT-2,5-HT-2A,Serotonin receptor 2A
5E
(R)		(2~{R})-1-(4-iodanyl-2,5-dimethoxy-phenyl)propan-2-aminenon-polymer321.21Chemie (A1EK5)
6F
(R)		CHOLESTEROLnon-polymer386.71Chemie (CLR)
PubChem (16219173)
PubChem (16758052)
PubChem (176980071)
PubChem (18640088)
PubChem (1715243)
PubChem (1715244)
PubChem (23423981)
PubChem (44654663)
PubChem (46937002)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (59274407)
PubChem (45044259)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (5997)
PubChem (1551269)
PubChem (90070115)
PubChem (49853509)
PubChem (50990013)
PubChem (117965027)
PubChem (6432564)
PubChem (6710666)
PubChem (124146240)
PubChem (52934537)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (10861996)
PubChem (56621683)
PubChem (132837164)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (138967089)
PubChem (139566851)
PubChem (15939944)
PubChem (57915018)
PubChem (57939063)
PubChem (58428240)
PubChem (58445498)
PubChem (58663286)
PubChem (171828367)
PubChem (173516975)
PubChem (59450329)
PubChem (59628412)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (89951918)
PubChem (90224410)
PubChem (91298236)
PubChem (101624109)
PubChem (304)
PubChem (124225449)
PubChem (191463)
PubChem (368063)
PubChem (369319)
PubChem (124429284)
PubChem (638019)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (1549081)
PubChem (1553803)
PubChem (5283629)
PubChem (5284644)
PubChem (5315842)
PubChem (6419195)
PubChem (6994560)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (11463329)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (130459183)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
PubChem (131992107)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
7G
(R)		waterwater18.013Chemie (HOH)
Sequence modifications
A: 1 - 19 (UniProt: P63096)
A: 20 - 60 (UniProt: P63092)
PDBExternal DatabaseDetails
Arg 32Ala 39conflict
Leu 34His 41conflict
Asp 42Gly 49conflict
Asn 43Glu 50conflict
Tyr 56Leu 63conflict
A: 61 - 180 (UniProt: P63096)
PDBExternal DatabaseDetails
Ser 108Phe 108conflict
A: 181 - 228 (UniProt: P63092)
PDBExternal DatabaseDetails
Ala 203Gly 226conflict
Asp 226Ala 249conflict
A: 231 - 346 (UniProt: P63092)
PDBExternal DatabaseDetails
Asp 229-linker
Tyr 230-linker
Asp 239Leu 272conflict
Lys 310Asp 343conflict
Val 313Leu 346conflict
Asp 314Arg 347conflict
Ile 325Tyr 358conflict
Ser 333Ala 366conflict
Ala 339Ile 372conflict
Ile 342Val 375conflict
A: 347 - 361 (UniProt: P50148)
PDBExternal DatabaseDetails
Ile 349Thr 347conflict
Met 353Leu 351conflict
Arg 356Lys 354conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight139591.3
Non-Polymers*Number of molecules2
Total formula weight707.8
All*Total formula weight140299.1
*Water molecules are not included.

253795

PDB entries from 2026-05-20

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