9LL9

DOI-bound Serotonin 2A (5-HT2A) receptor-Gq complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	340	37416.9	1	UniProt (P62873) Pfam (PF25391)	Homo sapiens (human)	Transducin beta chain 1
2	B (C)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	1	UniProt (P59768) Pfam (PF00631)	Homo sapiens (human)	G gamma-I
3	C (A)	Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(q) subunit alpha	polymer	361	41664.3	1	UniProt (P63096) UniProt (P63092) UniProt (P50148) Pfam (PF00503)	Homo sapiens (human)	Adenylate cyclase-inhibiting G alpha protein,Adenylate cyclase-stimulating G alpha protein,Guanine nucleotide-binding protein alpha-q
4	D (R)	5-hydroxytryptamine receptor 2A	polymer	471	52648.9	1	UniProt (P28223) Pfam (PF00001)	Homo sapiens (human)	5-HT-2,5-HT-2A,Serotonin receptor 2A
5	E (R)	(2~{R})-1-(4-iodanyl-2,5-dimethoxy-phenyl)propan-2-amine	non-polymer		321.2	1	Chemie (A1EK5)
6	F (R)	CHOLESTEROL	non-polymer		386.7	1	Chemie (CLR)
7	G (R)	water	water		18.0	13	Chemie (HOH)

Sequence modifications

A: 1 - 19 (UniProt: P63096)
A: 20 - 60 (UniProt: P63092)

A: 61 - 180 (UniProt: P63096)

PDB	External Database	Details
Ser 108	Phe 108	conflict

A: 181 - 228 (UniProt: P63092)

PDB	External Database	Details
Ala 203	Gly 226	conflict
Asp 226	Ala 249	conflict

A: 231 - 346 (UniProt: P63092)

A: 347 - 361 (UniProt: P50148)

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.