9LHV

Cryo-EM structure of GPR155 contracted dimer in complex with cholesterol

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Lysosomal cholesterol signaling protein	polymer	909	101046.0	2	UniProt (Q7Z3F1) Pfam (PF03547) Pfam (PF00610)	Homo sapiens (human)	LYCHOS,G-protein coupled receptor PGR22
2	C, E (A, B)	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	2	Chemie (Y01)
3	D, F (A, B)	CHOLESTEROL	non-polymer		386.7	2	Chemie (CLR)

Sequence modifications

A, B: 1 - 870 (UniProt: Q7Z3F1)

PDB	External Database	Details
Ala 871	-	expression tag
Ala 872	-	expression tag
Ala 873	-	expression tag
Glu 874	-	expression tag
Asn 875	-	expression tag
Leu 876	-	expression tag
Tyr 877	-	expression tag
Phe 878	-	expression tag
Gln 879	-	expression tag
Gly 880	-	expression tag
Leu 881	-	expression tag
Trp 882	-	expression tag
Ser 883	-	expression tag
His 884	-	expression tag
Pro 885	-	expression tag
Gln 886	-	expression tag
Phe 887	-	expression tag
Glu 888	-	expression tag
Lys 889	-	expression tag
Gly 890	-	expression tag
Gly 891	-	expression tag
Gly 892	-	expression tag
Ser 893	-	expression tag
Gly 894	-	expression tag
Gly 895	-	expression tag
Gly 896	-	expression tag
Ser 897	-	expression tag
Gly 898	-	expression tag
Gly 899	-	expression tag
Ser 900	-	expression tag
Ala 901	-	expression tag
Trp 902	-	expression tag
Ser 903	-	expression tag
His 904	-	expression tag
Pro 905	-	expression tag
Gln 906	-	expression tag
Phe 907	-	expression tag
Glu 908	-	expression tag
Lys 909	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	202092.1
Non-Polymers*	Number of molecules	4
	Total formula weight	1746.8
All*	Total formula weight	203838.9

*Water molecules are not included.