9LEZ
Cryo-EM structure of human ZAC in complex with N-(4-(tert-butyl)thiazol-2-yl)-3-fluorobenzamide (TTFB)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (D, B, C, A, E) | Ligand-gated cation channel ZACN,Genome polyprotein | polymer | 705 | 78830.9 | 5 | UniProt (Q401N2) UniProt (B6F2F5) Pfam (PF02931) | Homo sapiens (human) | Ligand-gated ion channel zinc-activated 1,Ligand-gated ion-channel receptor L2,Zinc-activated channel |
| 2 | F, G, H, I, J... (F, G, H, I, J...) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 10 | In PDB GlyTouCan (G15407YE) | |||
| 3 | P, R, T, W, Y (D, B, C, A, E) | ~{N}-(4-~{tert}-butyl-1,3-thiazol-2-yl)-3-fluoranyl-benzamide | non-polymer | 278.3 | 5 | Chemie (A1EKJ) PubChem (881640) | |||
| 4 | Q, S, U, V, X (B, C, A, E) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) PubChem (32051) |
Sequence modifications
D, B, C, A, E: 1 - 412 (UniProt: Q401N2)
D, B, C, A, E: 468 - 705 (UniProt: B6F2F5)
| PDB | External Database | Details |
|---|---|---|
| Thr 152 | Ala 152 | engineered mutation |
| Ser 413 | - | linker |
| Asp 414 | - | linker |
| Leu 415 | - | linker |
| Glu 416 | - | linker |
| Val 417 | - | linker |
| Leu 418 | - | linker |
| Phe 419 | - | linker |
| Gln 420 | - | linker |
| Gly 421 | - | linker |
| Pro 422 | - | linker |
| Glu 423 | - | linker |
| Phe 424 | - | linker |
| Trp 425 | - | linker |
| Ser 426 | - | linker |
| His 427 | - | linker |
| Pro 428 | - | linker |
| Gln 429 | - | linker |
| Phe 430 | - | linker |
| Glu 431 | - | linker |
| Lys 432 | - | linker |
| Gly 433 | - | linker |
| Gly 434 | - | linker |
| Gly 435 | - | linker |
| Ser 436 | - | linker |
| Gly 437 | - | linker |
| Gly 438 | - | linker |
| Gly 439 | - | linker |
| Ser 440 | - | linker |
| Gly 441 | - | linker |
| Gly 442 | - | linker |
| Ser 443 | - | linker |
| Ala 444 | - | linker |
| Trp 445 | - | linker |
| Ser 446 | - | linker |
| His 447 | - | linker |
| Pro 448 | - | linker |
| Gln 449 | - | linker |
| Phe 450 | - | linker |
| Glu 451 | - | linker |
| Lys 452 | - | linker |
| Glu 453 | - | linker |
| Phe 454 | - | linker |
| Asp 455 | - | linker |
| Ile 456 | - | linker |
| Asp 457 | - | linker |
| Tyr 458 | - | linker |
| Lys 459 | - | linker |
| Asp 460 | - | linker |
| Asp 461 | - | linker |
| Asp 462 | - | linker |
| Asp 463 | - | linker |
| Lys 464 | - | linker |
| Ser 465 | - | linker |
| Arg 466 | - | linker |
| Met 467 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 394154.3 | |
| Branched | Number of molecules | 10 |
| Total formula weight | 5865.4 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1718.8 | |
| All* | Total formula weight | 401738.5 |
