9LCK
Cryo-EM structure of influenza polymerase bound to cRNA promoter
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Polymerase acidic protein | polymer | 716 | 82669.5 | 1 | UniProt (Q9Q0U9) Pfam (PF00603) | Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) | RNA-directed RNA polymerase subunit P2 |
| 2 | B (B) | RNA-directed RNA polymerase catalytic subunit | polymer | 757 | 86492.2 | 1 | UniProt (Q9Q0V0) Pfam (PF00602) | Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) | Polymerase basic protein 1,PB1,RNA-directed RNA polymerase subunit P1 |
| 3 | C (C) | PB2-S1 | polymer | 43 | 5009.7 | 1 | UniProt (P0DOG5) Pfam (PF20948) | Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) | Polymerase PB2 |
| 4 | D (D) | 3'-cRNA | polymer | 9 | 2775.7 | 1 | Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) | ||
| 5 | E (E) | 5'-cRNA | polymer | 18 | 5836.5 | 1 | Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) |
Sequence modifications
A: 1 - 716 (UniProt: Q9Q0U9)
B: 1 - 757 (UniProt: Q9Q0V0)
| PDB | External Database | Details |
|---|---|---|
| Ile 201 | Val 201 | conflict |
| Ile 504 | Leu 504 | conflict |
| Lys 536 | Arg 536 | conflict |
| Glu 544 | Arg 544 | conflict |
| Ala 553 | Glu 553 | conflict |
| Leu 585 | Pro 585 | conflict |
| Leu 586 | Phe 586 | conflict |
| Met 628 | Val 628 | conflict |
| Lys 716 | Arg 716 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Lys 97 | Glu 97 | conflict |
| Ile 113 | Val 113 | conflict |
| Asn 134 | Lys 134 | conflict |
| Gln 460 | Glu 460 | conflict |
| Ser 478 | Thr 478 | conflict |
| Phe 490 | Cys 490 | conflict |
| Ile 535 | Met 535 | conflict |
| Asn 536 | Asp 536 | conflict |
| Thr 558 | Pro 558 | conflict |
| Leu 598 | Pro 598 | conflict |
| Val 609 | Ala 609 | conflict |
| Cys 610 | Gly 610 | conflict |
| Arg 754 | Gly 754 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 182783.6 | |
| All* | Total formula weight | 182783.6 |
