9LBG

The crystal structure of the truncated PAK2 containing K278R mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Serine/threonine-protein kinase PAK 2	polymer	466	51725.1	2	UniProt (Q13177) Pfam (PF00786) Pfam (PF00069)	Homo sapiens (human)	Gamma-PAK,PAK65,S6/H4 kinase,p21-activated kinase 2,PAK-2,p58
2	C (B)	D-MALATE	non-polymer		134.1	1	Chemie (MLT)
3	D (B)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
4	E, F (A, B)	water	water		18.0	11	Chemie (HOH)

Sequence modifications

A, B: 82 - 524 (UniProt: Q13177)

PDB	External Database	Details
Met 59	-	initiating methionine
Gly 60	-	expression tag
Ser 61	-	expression tag
Ser 62	-	expression tag
His 63	-	expression tag
His 64	-	expression tag
His 65	-	expression tag
His 66	-	expression tag
His 67	-	expression tag
His 68	-	expression tag
Ser 69	-	expression tag
Ser 70	-	expression tag
Gly 71	-	expression tag
Leu 72	-	expression tag
Val 73	-	expression tag
Pro 74	-	expression tag
Arg 75	-	expression tag
Gly 76	-	expression tag
Ser 77	-	expression tag
His 78	-	expression tag
Met 79	-	expression tag
Ala 80	-	expression tag
Ser 81	-	expression tag
Arg 278	Lys 278	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	103450.3
Non-Polymers*	Number of molecules	2
	Total formula weight	230.1
All*	Total formula weight	103680.4

*Water molecules are not included.