9L2F

Structure of SARM1 bound to M1 and 1AD in the active state

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	NAD(+) hydrolase SARM1	polymer	732	80483.1	8	UniProt (Q6SZW1) Pfam (PF07647) Pfam (PF13676)	Homo sapiens (human)	NADase SARM1,hSARM1,NADP(+) hydrolase SARM1,Sterile alpha and Armadillo repeat protein,Sterile alpha and TIR motif-containing protein 1,Sterile alpha motif domain-containing protein 2,MyD88-5,SAM domain-containing protein 2,Tir-1 homolog,HsTIR
2	I, J, K, L, M... (A, B, C, D, E...)	[(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(3-sulfanylpyridin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate	non-polymer		324.3	8	Chemie (A1EIV)

Sequence modifications

A, B, C, D, E, F, G, H: 1 - 724 (UniProt: Q6SZW1)

PDB	External Database	Details
Asp 725	-	expression tag
Tyr 726	-	expression tag
Lys 727	-	expression tag
Asp 728	-	expression tag
Asp 729	-	expression tag
Asp 730	-	expression tag
Asp 731	-	expression tag
Lys 732	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	643865.1
Non-Polymers*	Number of molecules	8
	Total formula weight	2594.1
All*	Total formula weight	646459.2

*Water molecules are not included.