9L0O
Cryo-EM structure of human lipid phosphate phosphatase 1 complexed with LPA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (C, A, B, D) | Phospholipid phosphatase 1 | polymer | 284 | 32126.0 | 4 | UniProt (O14494) Pfam (PF01569) | Homo sapiens (human) | Lipid phosphate phosphohydrolase 1,PAP2-alpha,Phosphatidate phosphohydrolase type 2a,Phosphatidic acid phosphatase 2a,PAP-2a,PAP2a |
| 2 | E, L, P, U (C, A, B, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 3 | F, M, Q, V (C, A, B, D) | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine | non-polymer | 760.1 | 4 | Chemie (LBN) | |||
| 4 | G, N, R, W (C, A, B, D) | [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate | non-polymer | 1047.1 | 4 | Chemie (PT5) | |||
| 5 | H, O, S, X (C, A, B, D) | (2R)-2-hydroxy-3-(phosphonooxy)propyl hexadecanoate | non-polymer | 410.5 | 4 | Chemie (NKO) | |||
| 6 | I, J, K, T (C, A, D) | 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE | non-polymer | 648.9 | 4 | Chemie (LPP) | |||
| 7 | AA, BA, Y, Z (B, D, C, A) | water | water | 18.0 | 12 | Chemie (HOH) |
Sequence modifications
C, A, B, D: 1 - 284 (UniProt: O14494)
| PDB | External Database | Details |
|---|---|---|
| Ala 171 | His 171 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 128503.9 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 12351.0 | |
| All* | Total formula weight | 140854.8 |
