9L0M
Structure of gain-of-function polycystin-1/polycystin-2 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Polycystin-1 | polymer | 1262 | 138627.8 | 1 | UniProt (P98161) Pfam (PF01477) Pfam (PF20519) Pfam (PF08016) | Homo sapiens (human) | PC1,Autosomal dominant polycystic kidney disease 1 protein |
| 2 | B, C, D (B, C, D) | Polycystin-2 | polymer | 1005 | 113313.7 | 3 | UniProt (Q13563) Pfam (PF20519) Pfam (PF00520) Pfam (PF08016) Pfam (PF18109) | Homo sapiens (human) | PC2,Autosomal dominant polycystic kidney disease type II protein,Polycystic kidney disease 2 protein,Polycystwin,R48321,Transient receptor potential cation channel subfamily P member 2 |
| 3 | E, F, G, H, I... (B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) |
Sequence modifications
A: 3052 - 4303 (UniProt: P98161)
B, C, D: 1 - 968 (UniProt: Q13563)
| PDB | External Database | Details |
|---|---|---|
| Met 3043 | - | initiating methionine |
| Asp 3044 | - | expression tag |
| Tyr 3045 | - | expression tag |
| Lys 3046 | - | expression tag |
| Asp 3047 | - | expression tag |
| Asp 3048 | - | expression tag |
| Asp 3049 | - | expression tag |
| Asp 3050 | - | expression tag |
| Lys 3051 | - | expression tag |
| Leu 4304 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -36 | - | initiating methionine |
| Gly -35 | - | expression tag |
| Ala -34 | - | expression tag |
| Ser -33 | - | expression tag |
| Ser -32 | - | expression tag |
| Ala -31 | - | expression tag |
| Trp -30 | - | expression tag |
| Ser -29 | - | expression tag |
| His -28 | - | expression tag |
| Pro -27 | - | expression tag |
| Gln -26 | - | expression tag |
| Phe -25 | - | expression tag |
| Glu -24 | - | expression tag |
| Lys -23 | - | expression tag |
| Gly -22 | - | expression tag |
| Gly -21 | - | expression tag |
| Gly -20 | - | expression tag |
| Ser -19 | - | expression tag |
| Gly -18 | - | expression tag |
| Gly -17 | - | expression tag |
| Gly -16 | - | expression tag |
| Ser -15 | - | expression tag |
| Gly -14 | - | expression tag |
| Gly -13 | - | expression tag |
| Ser -12 | - | expression tag |
| Ala -11 | - | expression tag |
| Trp -10 | - | expression tag |
| Ser -9 | - | expression tag |
| His -8 | - | expression tag |
| Pro -7 | - | expression tag |
| Gln -6 | - | expression tag |
| Phe -5 | - | expression tag |
| Glu -4 | - | expression tag |
| Lys -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Ala 677 | Leu 677 | engineered mutation |
| Ala 681 | Asn 681 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 478569.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1327.2 | |
| All* | Total formula weight | 479896.3 |
